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Columbia University, UT-Battelle, Affymetrix, NVE Corporation

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The Trustees of Columbia University received US Patent No. 6,743,630, “Method of preparing a protein array based on biochemical protein-protein interaction.” The patent covers a method of preparing a protein array based on biochemical protein-protein interactions. The array begins with a first protein, which includes a PDZ domain, deposited on a substrate. A second protein is applied to the array and bound to the PDZ domain of the first protein. This protein includes a specific amino acid sequence described thusly: (S/T)—X—(V/I/L)-COOH. According to the patent, each hyphen represents a peptide bond, each parenthesis encloses amino acids which are alternatives to one other, each slash within such parentheses separates the alternative amino acids, and the X represents any amino acid that is selected from the group comprising the twenty naturally occurring amino acids.


UT-Battelle of Oak Ridge, Tenn., received US Patent No. 6,743,581, “Multifunctional and multispectral biosensor devices and methods of use.” The patent covers an integrated biosensor system for the simultaneous detection of different types of targets and includes at least one sampling platform. The receptors include at least one protein receptor and at least one nucleic acid receptor. At least one excitation source of electromagnetic radiation at a first frequency is provided for irradiating the receptors, wherein electromagnetic radiation at a second frequency different from the first frequency is emitted when at least one of the different types of targets are bound to the receptor probes. An integrated circuit detector system having a detection channels is also provided for detecting electromagnetic radiation at the second frequency.


Affymetrix received US Patent No. 6,743,882, “Functionalized silicon compounds and methods for their synthesis and use. The patent covers functionalized silicon compounds and methods for their synthesis and use. The compounds include at least one activated silicon group and at least one derivatizable functional group. The compounds may be covalently attached to surfaces to form functionalized surfaces that may be used in a wide range of different applications. When the compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, they provide a surface, to which molecules, including polypeptides and nucleic acids, may be attached. The patent holder considers this a method that permits the formation of high density arrays of nucleic acids for conducting high-volume nucleic acid hybridization assays.


NVE Corporation of Eden Prairie, Minn., received US Patent No. 6,743,639, “Magnetizable bead detector.” The patent covers a ferromagnetic thin-film-based magnetic field detection system used for detecting the presence of selected molecular species. A magnetic field sensor supported on a substrate has a binding molecule layer positioned on a side capable of selectively binding to the selected molecular species.

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