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Columbia University, University of Michigan, Bio-Rad Laboratories, Li-Cor, Affymetrix

Columbia University of New York has received US Patent No. 7,277,574, “Methods and systems for feature selection.” The patent claims methods and systems for feature selection, data classification, retrieval, and segmentation. Parts of the patent are directed to methods and systems for complement sort-merge tree, fast-converging sort-merge tree, and multi-level feature selection. According to the patent, methods can be used for selecting features in text, images, audio, video, gene microarray data, and handwriting.

The University of Michigan of Ann Arbor, Mich., has received US Patent No. 7,279,281, “Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases.” The patent describes methods for diagnosing, monitoring, and treating an autoimmune or chronic inflammatory disease. Specifically, the methods are based on detecting or altering autoimmune or chronic inflammatory disease proteins, such as CD70 and CD40L. The patent also claims kits for detecting the methylation status of autoimmune or chronic inflammatory disease proteins and for diagnosing, monitoring, and treating autoimmune or chronic inflammatory diseases by use of antibody binding, oligonucleotide-binding assays, or microarray.

Bio-Rad Laboratories of Hercules, Calif., has received US Patent No. 7,279,814, “Moving coil actuator for reciprocating motion with controlled force distribution.” The patent describes moving coil actuators that can be used as a driving mechanism for reciprocating motion of an optical system. According to the patent, the moving coil actuator that moves in a rapid back-and-forth motion is constructed with a magnet assembly that concentrates the magnetic flux in a region of limited length and with a coiled electric conductor that includes two separated regions of densely wound coil, the assembly and conductor arranged such that only one of the coil regions resides in a concentrated flux region at either end of the actuator stroke. This setup results in an efficient use of the electric current and can be used in scanning systems for microarrays where very rapid illumination, observation, and detection is performed at a large number of individual sites arranged in a regular two-dimensional array.

Li-Cor of Lincoln, Neb., has received US Patent No. 7,280,205, “On-chip spectral filtering using CCD array for imaging and spectroscopy.” The patent claims a spectral filtering apparatus and method that enables the functions of hyperspectral imaging to be performed with increased speed, simplicity, and performance. The spectral filtering technique can be applied to various multi-spectral and hyperspectral imaging methods that use array detectors. According to the patent, the technology can be easily applied to develop a microarray imaging system with comparable capabilities.

Affymetrix has received US Patent No. 7,280,922, “System, method, and computer software for genotyping analysis and identification of allelic imbalance.” The patent claims methods, systems and computer software products for determining the genotype of a sample using a plurality of probes. According to the patent, the method for determining a change of genotype between two samples from an individual includes: a) receiving a plurality of probe intensity values; b) calculating a first genotyping data value and a second genotyping data value using one or more of the probe intensity values associated with a first strand and one or more of the probe intensity values associated with a second strand; c) calculating a difference value using the first genotyping data value and the second genotyping data value; d) normalizing the difference value using a normalization value for the first strand and a normalization value for the second strand; and e) determining a change of genotype call.

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.