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Columbia University, Amersham Biosciences, Applera

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Columbia University has received US Patent No. 6,664,079, “Massive parallel method for decoding DNA and RNA,” for an invention by Jingyue Ju et al. The patent describes methods for attaching a nucleic acid to a solid surface, and then incorporating nucleotide analogues into a strand of DNA in a polymerase reaction, and using the nucleotide analogues to identify the identity of the bases attached to the surface in order to sequence this attached nucleic acid. The method details the nucleotide analogues, which are labels attached to the analog using a cleavable linker and a cleavable chemical group to cap the -OH group at the 3’ position on the deoxyribose.


Amersham Biosciences (which is slated to be acquired by GE), received US patent No. 6,664,061, “Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix.” The patent covers the use and evaluation of the 2+2 photoaddition to immobilize oligonucleotides on such a hydrogel matrix. This patent follows on one the company received earlier this year, No. 6,500,921, “Schiff base reductant co-dispense process,” which covers methods for producing a covalent linkage with chemical stability between an amine-containing biomolecule and a solid support or hydrogel surface containing an aldehyde moiety.


Applera, the parent company of Applied Biosystems, has received US Patent No. 6,664,388, “Reagents for oligonucleotide cleavage and deprotection.” The patent covers a process for removing protecting groups from chemically synthesized oligonucleotides, and in one case, reagents and kits that can be used in such a process. The technology is designed to minimize side-reactions that can contaminate synthetic oligonucleotides, according to the patent. The oligonucleotide deprotection methods involve reacting a protected oligonucleotide with a deprotection reagent that includes an active methylene compound and an amine reagent.

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