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Cold Spring Harbor Laboratory, BioArray Solutions

Cold Spring Harbor Laboratory has received US Patent No. 7,358,049, “Gene chip technology for determining memory genes.” The patent claims a method of identifying a gene or genes involved in transcription-dependent memory by: a) training non-human animals under conditions sufficient to induce transcription-dependent memory formation; b) extracting RNA from brain tissue of said non-human animals; c) synthesizing DNA probes using the RNA; d) exposing the DNA probes to microarray chips containing DNA sequences from genes of the genome of said non-human animals under conditions appropriate for hybridization of the DNA probes to complementary DNA sequences on the microarray chips; e) detecting the signal; and f) performing a statistical comparison between the signal detected in step (e) and the signal detected in a control.

BioArray Solutions of Warren, NJ, has received US Patent No. 7,358,097, “Making a matrix of random encoded arrays.” The patent claims an apparatus and method of maintaining chips or arrays of particles, or arrays of particles deposited on chip surfaces, in a designated area on a substrate surface. This is accomplished by having hydrophilic chips or arrays of particles, and a substrate that has a series of hydrophilic regions designed to accommodate the chips/arrays of particles, surrounded by hydrophobic regions. In the presence of aqueous solution, the chips or arrays of particles are held in the designated regions, the patent states.

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.