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Cold Spring Harbor Laboratory, Agilent Technologies, Agilent, Attomol Molecular Diagnostics, ViaLogy


Cold Spring Harbor Laboratory, of Cold Spring Harbor, NY, has received US Patent No. 7,005,256, "Gene chip technology for determining memory genes." The patent describes methods of identifying genes involved in memory formation by performing a gene chip identification of those genes expressed during transcription-dependent memory. A statistical analysis of the gene chip identification output yields a set of genes that are involved in transcription-dependent memory format, according to the patent.

Agilent Technologies of Palo Alto, Calif., has received US Patent No. 7,005,293, "Multiple axis printhead adjuster for non-contact fluid deposition devices." The patent claims non-contact fluid deposition devices having multiple axis printhead adjusters. The printhead adjusters are made up of a single rigid frame that holds at least one printhead housing, where multiple printhead housings are held in side-by-side configuration in the single rigid frame of the adjuster, the patent claims. The invention is used by loading the adjuster with a volume of fluid, and then placing the loaded printhead in opposing relation to a surface of a substrate and actuated to deposit a volume of fluid on the substrate in order to produce biopolymeric arrays.

Agilent has also received US Patent No. 7,006,927, "Method and system for extracting data from surface array deposited features." The patent claims a method and system for extracting data signals from a scanned image resulting from optical, radiometric, or other types of analysis of a molecular array. Methods are also claimed where the positions of corner features are first located, then an initial feature coordinate grid is determined from the positions of the corner features. A refined feature coordinate grid is then calculated based on the positions of strong features, and is used to identify the positions of weak features and the positions of the local background regions surrounding all features. Signal intensity values are then extracted from the features and their respective local background regions in the scanned image, and background-subtracted signal intensity values, background-subtracted and normalized signal intensity ratios, and variability information and confidence intervals are determined based on the extracted values.

Attomol Molecular Diagnostics of Lipten, Germany, has received US Patent No. 7,005,294, "Method for producing an array for detecting constituents from a biological sample." The patent describes a method of producing an array for the detection of components from a biological sample, where the detection molecules are immobilized on one or more supports, the supports are embedded and subjected to curing, the supports is separated into sections, and the sections are applied on another support.

ViaLogy of Altadena, Calif., has received US Patent No. 7,006,680, "System and method for characterizing microarray output data." The patent claims a spectral transformation technique for characterizing digitized intensity output patterns from microarrays. Methods are also claimed that include the steps of extracting pixels associated with an object of interest and transforming such pixels from an intensity representation to a spectral representation.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.