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Clondiag Chip Technologies, Agilent Technologies, Applera, Eppendorf, Seiko Epson, Sandia, Affymetrix

Clondiag Chip Technologies of Jena, Germany, has received European Patent No. 1807209, “Devices for carrying out and diagnosing microarray experiments.” The patent claims devices for carrying out parallel microarray experiments for detecting specific interactions between probe and target molecules in a microtiter plate and to methods for producing those devices. The patent also relates the use of these devices in a method for the qualitative and/or quantitative detection of specific interactions between probe and target molecules, according to the patent’s abstract.

Agilent Technologies has received European Patent No. 1807535 "Array-based methods for producing ribonucleic acids.” The patent describes methods and compositions for generating pluralities of ribonucleic acids where an array is employed as a template in an in vitro transcription reaction. Also claimed are the arrays employed in the described methods as well as kits for practicing those methods. According to the patent’s abstract, the ribonucleic acid produced by these methods can be used in a variety of different applications, such as differential gene expression analysis and gene-silencing applications.
Agilent has also received US Patent No. 7,252,938, “Methods and devices for producing a polymer at a location of a substrate.” The patent claims methods and devices for producing a polymer on a substrate. In the methods, a fluid droplet containing a first monomer labeled with a first detectable label is deposited from a fluid deposition device onto a substrate surface coated with a second monomer labeled with a second detectable label. The first and second detectable labels are then detected to determine any misalignment between the fluid deposition device and the location of the substrate surface during deposition. Also described are algorithms that perform the methods, as well as fluid deposition devices that include the claimed algorithms. The patent also covers arrays produced according to the methods and kits that include those arrays.

Applera has received European Patent No. 1809768, "Two-color chemiluminescent microarray system.” The patent claims a two-color target molecule assay system that utilizes two chemiluminescent molecules that have different light-emitting properties. Methods for detecting different target molecules at the same time using two chemiluminescent enzymes having different light emitting properties are also described.

Eppendorf Array Technology of Namur, Belgium, has received European Patent No. 1812594, "Real-time quantification of multiple targets on a microarray.” The patent claims a method and apparatus for monitoring a real-time quantification of multiple target molecules during their binding on capture molecules of a microarray. The method comprises the steps of: a) placing in a chamber a support that has an array fixed upon its surface; b) introducing labeled target molecules solution into the chamber; c) incubating the labeled target molecules under stable and controlled temperature conditions to allow the binding between the target and capture molecules; d) directing an excitation light from a light source on the surface of the microarray; and e) measuring the electromagnetic light emission from the bound target molecules.

Seiko Epson of Tokyo has received US Patent No. 7,253,006, “Device and method for manufacturing bead array, and method for detecting target substance.” The patent describes a device for manufacturing a bead array. The device includes a container, a liquid including a bead having a biological substance fixed on a surface of the bead, and a means for ejecting the liquid including the bead on a desired position on a solid-phase base.

Sandia of Albuquerque, NM, has received US Patent No. 7,253,008, “Reactive ion etched substrates and methods of making and using.” The patent claims substrates comprising reactive ion etched surfaces and specific binding agents immobilized on them. According to the patent’s abstract, the substrates may be used in methods and devices for assaying or isolating analytes in a sample. Also described are methods of making the reactive ion etched surfaces.

Affymetrix has received US Patent No. 7,252,948, “Chip-based speciation and phenotypic characterization of microorganisms.” The patent describes oligonucleotide-based arrays and methods for assigning an organism to a group or species by detecting at least one polymorphism at a position of interrogation in a target nucleic acid sequence. The methods include: a) providing a plurality of different probes complementary to one or more reference nucleic acid sequences that are immobilized on a surface; b) hybridizing the target nucleic acid sequence to the probes in the array; c) hybridizing the reference nucleic acid sequence to the probes in a separate, identical array; d) comparing the hybridization pattern of step b to the hybridization pattern of step c; and e) detecting at least one polymorphism at the position of interrogation, where the detecting allows the assignment of an organism to a group or species.

The Scan

Could Mix It Up

The US Food and Drug Administration is considering a plan that would allow for the mixing-and-matching of SARS-CoV-2 vaccines and boosters, the New York Times says.

Closest to the Dog

New Scientist reports that extinct Japanese wolf appears to be the closest known wild relative of dogs.

Offer to Come Back

The Knoxville News Sentinel reports that the University of Tennessee is offering Anming Hu, a professor who was acquitted of charges that he hid ties to China, his position back.

PNAS Papers on Myeloid Differentiation MicroRNAs, Urinary Exosomes, Maize Domestication

In PNAS this week: role of microRNAs in myeloid differentiation, exosomes in urine, and more.