Clinomics Biosciences of Pittsfield, Mass., received US Patent No. 6,534,307, “Frozen tissue microarrayers.” The patent covers a system for creating microarrays from frozen tissue samples. The device comprises: a cooling chamber for receiving at least one frozen material sample and for maintaining the material in a frozen condition; the cooling chamber moveable in an x and y direction relative to a horizontal surface; at least one coring needle comprising a cutting surface and a lumen for receiving a core of frozen material cut by the cutting surface; and at least one element for positioning the frozen material for cutting it. The patent also covers a method for generating frozen tissue microarray blocks.
LG Electronics of Seoul, South Korea, received US Patent No. 6,534,270, “Biochip and method for fabric-ating the same.” The patent covers a system for creating a biochip. In this method, a solid support wound with fibers is immersed in a solution to immobilize biomolecules onto the fiber, which are then straightened and arranged. The arranged fibers are embedded with a defined material and cut in a direction perpendicular to the lengthwise arrangement direction of the fibers to obtain thin chips. The chips are placed on a substrate to remove the material used for embedding, leaving the fibers with the immobilized biomolecules on the substrate. This biochip fabrication method immobilizes a great number of biomolecules onto the fibers having a large surface area in order to enhance the detection sensitivity and allows production of a large number of substrates simultaneously.
Xiaodong Wang of the University of Texas Southwestern Medical Center at Dallas received US Patent No. 6,534,267, “Polynucleotides encoding activators of caspases.” The patent identifies sequences of human polypeptide activators of caspases such as polypeptide and polynucleotide sequences that indicate activators and can be used in proteomic microarrays.
The Albert Einstein College of Medicine of Yeshiva University of the Bronx, NY, received US Patent No. 6,534,266, “Assay of transcription sites by multi-fluor FISH.” The patent covers an in situ hybridization method for detecting and specifically identifying the transcription of a number of target sequences in a cell.