Casting Doubt on GWAS, Duke Team Advocates Sequencing-First Approach to ID Rare Causal Variants | GenomeWeb

By Justin Petrone

Sequence first, genotype second. That is the message of a new study published last week in the American Journal of Human Genetics.

Led by David Goldstein, director of the Duke University Center for Human Genome Variation, the scientists sequenced the complete genomes of 29 people of European origin to assess the relationship between the functional properties of variants and their population allele frequencies.

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