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CapitalBio Corp., University of Tsinghua, Protagen, Sumitomo Bakelite, DNA Chip Research, Kenji Kinoshita, Aperio Technologies, Illumina, Agilent Technologies, Biocept, Afshin Ahmadian, Joakim Lundeberg, Clondiag Chip Technologies, Dr. Chip Biotechnology

CapitalBio Corp. and the University of Tsinghua, both of Beijing, have received European Patent No.  1816476, “A testing method of nucleic acid binding protein based on biochip.” The patent claims a testing method for a nucleic acid-binding protein based on a biochip, comprising the following steps: a) put a solution including nucleic acid-captured probes into a biological sample, forming nucleic acid-captured probe-nucleic acid-binding protein complexes; b) separate the nucleic acid-captured probe-nucleic acid-binding protein complexes, then recover nucleic acid captured probes; c) hybridize the nucleic acid-captured probes according to step b with a single-strand blotting probes on biochip substrate; and d) detect the result of that hybridization.

Protagen has received European Patent No. 1817586, “Protein-biochip for validating binding agents.” The patent describes an arrangement of proteins containing at least one cDNA-expression library and to the use of the proteins in a protein-biochip for validating binding agents and protein binding agents. A method for determining in a simultaneous manner quantitative variables is also claimed.

Sumitomo Bakelite, DNA Chip Research, and Kenji Kinoshita, all of Tokyo, have received European Patent No. 1820857, “DNA chain elongation method, DNA chain amplification method and microarray for DNA chain elongation.” A primer for DNA elongation is immobilized to a substrate having a polymer, which comprises a first unit having a group induced from a phosphate constituting the hydrophilic moiety of a phospholipid and a second unit having an active ester group, on its surface. Then, a reaction system, into which a template DNA fragment having a desired sequence and a sample containing a nucleotide monomer have been introduced, is heated to a temperature at which the DNA chain is thermally denatured. Next, the temperature of the above reaction system is lowered to a temperature for performing an annealing treatment and the DNA chain elongation is carried out in this reaction system.

Aperio Technologies has received US Patent No. 7,257,268, “Systems and methods for image pattern recognition.” The patent claims systems and methods for image pattern recognition that comprise digital image capture and encoding using vector quantization of the image. A vocabulary of vectors is first built by segmenting images into kernels and creating vectors corresponding to each kernel. Images are then encoded by creating a vector index file having indices that point to the vectors stored in the vocabulary. The vector index file can be used to reconstruct an image by looking up vectors stored in the vocabulary. Pattern recognition of candidate regions of images can be accomplished by correlating image vectors to a pre-trained vocabulary of vector sets comprising vectors that correlate with particular image characteristics. In virtual microscopy, the systems and methods are suitable for rare-event finding, such as detection of micrometastasis clusters, tissue identification, such as locating regions of analysis for immunohistochemical assays, and rapid screening of tissue samples, such as histology sections arranged as tissue microarrays, the patent claims.

Illumina has received US Patent No. 7,259,258, “Methods of attaching biological compounds to solid supports using triazine.” The patents claim methods for attaching biologically active compounds to a solid surface by modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety.

Agilent Technologies has received US Patent No. 7,258,834, “Methods and devices for modifying a substrate surface.” The patent claims methods and compositions for modifying a substrate surface where the surface is contacted with a particulate-containing fluid. The fluid is then ultrasonically or sonically agitated to modify the substrate surface. In certain embodiments, the particulate-containing fluid has a pH above the isoelectric point of the substrate. Also provided are devices capable of providing ultrasonic and/or sonic energy and which include a non-acidic, particulate-containing fluid. The patent also describes systems and kits for use in practicing the subject methods.

Biocept of San Diego has received US Patent No. 7,258,990, “Alleviation of non-specific binding in microarray assays.” The patent describes a method where a post-incubation treatment is employed to effectively remove targets, such as proteins/protein complexes, or other label-bearing moieties that may non-specifically bind to a microarray substrate during a binding assay. Following incubation, a one-step wash is carried out with a liquid containing digester, such as a digestive enzyme or lysosome, that can remove non-specifically bound targets or at least labeled portions of such targets from the substrate. Proteases are bound to or coated onto large molecules or onto solid particles of such a size such that they are prohibited from entering the porous surfaces of 3D hydrogel microspots and are unable to reach and digest labeled target-probe complexes that are disposed within such porous hydrogel microspots. Digested segments of such protein that contain labels are carried away in the wash liquid and are not present to create background noise during imaging.

Afshin Ahmadian and Joakim Lundeberg of Stockholm, Sweden, have received US Patent No. 7,262,032, “Allele-specific mutation detection assay using an enzyme-disabling agent.” The patent claims a method of detecting a base at a pre-determined position in a nucleic acid molecule by performing enzymatic detection reactions using base-specific detection oligomers, where each oligomer is specific for a particular base at the predetermined position, and then comparing the enzymatic detection reactions to determine which base is present at the position, with an enzyme-disabling agent being present during the enzymatic detection reaction. In preferred embodiments the enzymatic detection reaction is an oligomer elongation extension reaction, catalysed by, among others, polymerase or ligase. Also disclosed are methods of performing the assay in a liquid phase and on microarrays.

Clondiag Chip Technologies of Jena, Germany, has received US Patent No. 7,262,842, “Device for referencing fluorescence signals.” The patent describes a device for referencing fluorescence signals and/or calibration of fluorescence detection systems, where the device comprises a non-fluorescing support on which are applied polymer layers in several defined regions and with partly varying thicknesses and/or compositions. The polymer layers are applied to the support such as to create fluorescence after corresponding irradiation and the device may be used as a fluorescence standard. The patent also describes a method for the production of these fluorescence standards.

Dr. Chip Biotechnology of Chu-nan, Taiwan, has received US Patent No. 7,262,858, “Apparatus and method for accessing and processing reflection image from microwell-plate-based biochip.” The patent claims an apparatus that accesses and processes reflection images detected from microarray biochips with sidewalls. The apparatus uses a movable system to carry an optical module and a microtiter plate to achieve relative movement in different directions, so that pattern images of all wells in the microtiter plate can be retrieved during a single scanning process. Scanned image data are further compared with pre-defined patterns by a computer program for analysis.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.