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Canon Kabushiki Kaisha, Zyomyx, Biolog


Canon Kabushiki Kaisha of Tokyo earned US Patent No. 6,476,215, “Ink jet method of spotting a probe and manufacturing a probe array.” The patent covers a method of spotting a probe densely and efficiently on a surface of a solid support. A liquid is attached as droplets by ink jet to form spots containing the probe.

Zyomyx of Hayward, Calif., was awarded US Patent No. 6,475,809, “Protein arrays for high-throughput screening.” The patent covers a design for protein arrays and protein-coated substrates where different members of a single protein family may be immobilized on the protein-coated substrate or array for parallel, high-throughput screening. The company also earned US Patent No. 6,475,808, “Arrays of proteins and methods of use thereof.” The patent covers arrays of organic thinfilms on a substrate surface holding different members of a single protein family.

Biolog of Hayward, Calif., has earned US Patent No. 6,387, 651, the company said this week. The patent was granted for comparative phenotypic analysis of two or more microorganisms, using a number of substrates within a microwell device. The patent covers methods and compositions for phenotypic analysis of eukaryotic as well as prokaryotic cells.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.