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Caliper Technologies, Affymetrix


Caliper Technologies received US Patent No. 6,632,655, “Manipulation of microparticles in microfluidic systems.” The patent covers a system of arrays of flowable or fixed particle sets that are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus, and integrated systems comprising arrays and array members.

Affymetrix received US Patent No. 6,632,611, “Method of target enrichment and amplification.” The patent, awarded October 14, covers methods and kits for amplifying a target sequence from within a population of nucleic acid molecules. The invention provides selection probes that are complementary to at least a part of the target sequence and mechanisms for adding a probe sequence to the 3’ end of a target sequence that is hybridized to a selection probe. The added 3’ probe sequence and a probe sequence added at the 5’ end of the target by adaptor ligation enable the target sequence to be selectively amplified.

Affymetrix also received US Patent No. 6,632,605, “Hybridization assays on oligonucleotide arrays.” The patent, awarded October 14, provides methods of performing nucleic acid hybridization assays on high-density substrate-bound oligonucleotide arrays that include in the hybridization mixture an isostabilizing agent, a denaturing agent, or a renaturation accelerant.


The Scan

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.

Analysis of Endogenous Parvoviral Elements Found Within Animal Genomes

Researchers at PLOS Biology have examined the coevolution of endogenous parvoviral elements and animal genomes to gain insight into using the viruses as gene therapy vectors.

Saliva Testing Can Reveal Mosaic CNVs Important in Intellectual Disability

An Australian team has compared the yield of chromosomal microarray testing of both blood and saliva samples for syndromic intellectual disability in the European Journal of Human Genetics.

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.