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Boston Probes, Syntrix Biochip, Ingeneus Corp.


Boston Probes received US Patent No. 6,607,889, “Methods, kits, and compositions pertaining to detection complexes.” The patent covers systems that utilize detection complexes to detect or identify the presence, absence, or quantity of a target molecule in a sample of interest. A detection complex comprises at least two component polymers and at least one set of donors and acceptors. Each of at least two component polymers is linked to at least one set of donors and acceptors, such that the formation of this complex facilitates the transfer of energy which, in an assay, produces changes in detectable signal which can be correlated with the presence or absence of quantity of target sequence and/or target molecule of interest in the sample.

Syntrix Biochip of Redmond, Wash., received US Patent No. 6,569,598, “Solvent resistant photosensitive compositions.” The patent covers a system of photoresist compositions for preparing films that are stable and impermeable to a broad range of organic solvents. The films provided may be photopatterned by selectively applying light, and may be stripped from a surface using unreactive agents. Photopatterned films may be used, for example, to selectively direct organic reagents to a solid support for the purpose of performing regionally selective solid-phase chemical synthesis with micron-scale resolution.

Ingeneus Corp. of Bridgetown, Barbados, received US Patent No. 6,613,524, “Amperometric affinity assay and electrically stimulated complexes of nucleic acids.” The patent covers a method for measuring the affinity of one nucleobase-containing sequence for a second by applying a voltage across the test medium; measuring a test electric current through the test medium; and determining the affinity by evaluating whether the test electric current is equivalent to a reference electric current of a reference medium containing a longer of either the first nucleobase-containing sequence or the second nucleobase-containing sequence. A complex in an electrically-stimulated phase contains at least two nucleobase-containing sequences in a medium, wherein the electrical conductivity of the medium increases linearly without a plateau as the temperature of the medium approaches and exceeds that of the complex.


The Scan

Review of Approval Process

Stat News reports the Department for Health and Human Services' Office of the Inspector General is to investigate FDA's approval of Biogen's Alzheimer's disease drug.

Not Quite Right

A new analysis has found hundreds of studies with incorrect nucleotide sequences reported in their methods, according to Nature News.

CRISPR and mRNA Together

Time magazine reports on the use of mRNA to deliver CRISPR machinery.

Nature Papers Present Smartphone Platform for DNA Diagnosis of Malaria, Mouse Lines for Epigenomic Editing

In Nature this week: a low-cost tool to detect infectious diseases like malaria, and more.