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BioDiscovery, Sequenom, Eastman Kodak, HRL Laboratories, Zyomyx


BioDiscovery received US Patent No. 6,731,781, “System and method for automatically processing microarrays.” The patent covers a digital image-processing system and a method for quantitatively processing the nucleic acids expressed in a microarray. The system includes a scanner that has a digital sensor that scans the microarray and transmits from an output a digital image of the microarray, and a processor that receives the digital image of the microarray from the scanner, and then processes the digital image, identifying each of the microarray’s sub-grids. The processor then detects in each of the sub-grids a center-representing pixel and an approximate radius of the signal. Then, the processor segments the signal and calculates a characterizing measurement for it.

Sequenom received US Patent No. 6,730,517, “Automated process line.” The patent covers an automated modular analytical system with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates. Analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemical tags, and fluorescence chemiluminescence, are integrated with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line.

Eastman Kodak received US Patent No. 6,730,515, “Microarray calibration means.” The patent covers a technology used to calibrate a microarray receiver. The apparatus includes a substrate coated with a biologically active region comprised of a first set of microspheres modified with a biological probe and containing an optical bar code generated from at least one colorant associated with the spheres; and a calibration region associated with the substrate.

HRL Laboratories of Malibu, Calif., received US Patent No. 6,730,212, “Sensor for chemical and biological materials.” The patent covers a sensor and a method for detecting biological and chemical agents comprising metal electrodes coated with hybrid, polymer-based conducting film and an instrument for applying electrical voltage.

Zyomyx received US Patent No. 6,730,516, “Microfluidic devices and methods.” The patent covers microfluidic devices having at least one transfer-separation channel with a channel bottom that has an opening.


The Scan

Back as Director

A court has reinstated Nicole Boivin as director of the Max Planck Institute for the Science of Human History, Science reports.

Research, But Implementation?

Francis Collins reflects on his years as the director of the US National Institutes of Health with NPR.

For the False Negatives

The Guardian writes that the UK Health Security Agency is considering legal action against the lab that reported thousands of false negative COVID-19 test results.

Genome Biology Papers Present Epigenetics Benchmarking Resource, Genomic Architecture Maps of Peanuts, More

In Genome Biology this week: DNA methylation data for seven reference cell lines, three-dimensional genome architecture maps of peanut lines, and more.