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BioDiscovery, Sequenom, Eastman Kodak, HRL Laboratories, Zyomyx


BioDiscovery received US Patent No. 6,731,781, “System and method for automatically processing microarrays.” The patent covers a digital image-processing system and a method for quantitatively processing the nucleic acids expressed in a microarray. The system includes a scanner that has a digital sensor that scans the microarray and transmits from an output a digital image of the microarray, and a processor that receives the digital image of the microarray from the scanner, and then processes the digital image, identifying each of the microarray’s sub-grids. The processor then detects in each of the sub-grids a center-representing pixel and an approximate radius of the signal. Then, the processor segments the signal and calculates a characterizing measurement for it.

Sequenom received US Patent No. 6,730,517, “Automated process line.” The patent covers an automated modular analytical system with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates. Analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemical tags, and fluorescence chemiluminescence, are integrated with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line.

Eastman Kodak received US Patent No. 6,730,515, “Microarray calibration means.” The patent covers a technology used to calibrate a microarray receiver. The apparatus includes a substrate coated with a biologically active region comprised of a first set of microspheres modified with a biological probe and containing an optical bar code generated from at least one colorant associated with the spheres; and a calibration region associated with the substrate.

HRL Laboratories of Malibu, Calif., received US Patent No. 6,730,212, “Sensor for chemical and biological materials.” The patent covers a sensor and a method for detecting biological and chemical agents comprising metal electrodes coated with hybrid, polymer-based conducting film and an instrument for applying electrical voltage.

Zyomyx received US Patent No. 6,730,516, “Microfluidic devices and methods.” The patent covers microfluidic devices having at least one transfer-separation channel with a channel bottom that has an opening.


The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.