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BioArray Solutions, New York Blood Center, Euclid Diagnostics, Affymetrix

BioArray Solutions of Warren, NJ, and New York Blood Center of New York have received US Patent No. 7,449,295, “Method of nucleic acid typing for selecting registered donors for cross-matching to transfusion recipients.” The patent claims a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes — and the underlying combinations of alleles and haplotypes. The method described, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others. The genotypes are obtained by profiling specific markers in a hybridization-based assay.

Euclid Diagnostics of Crown Point, Ind., has received US Patent No. 7,449,297, “Methods of copying the methylation pattern of DNA during isothermal amplification and microarrays.” The patent claims a method for copying the methylation patterns in double-stranded DNA molecules during isothermal amplification of the DNA molecules by: a) obtaining DNA molecules; b) contacting the DNA molecules with transposable elements and an enzyme, which can randomly insert the transposable elements into the DNA molecules; and c) copying the methylation patterns of the DNA molecules using a DNA methylation-maintenance enzyme, while isothermally amplifying the DNA molecules using a DNA polymerase with strand displacement activity, under conditions that simultaneously promote activity of the DNA methylation-maintenance enzyme and the DNA polymerase. The patent also includes a buffer comprising a divalent ion, deoxynucleotide triphosphates, primers, and S-adenosyl-methionine; and a composition comprising a DNA methylation-maintenance enzyme, a DNA polymerase with strand displacement activity, and the buffer.

Affymetrix has received US Patent No. 7,451,047, “System and method for programmatic access to biological probe array data.” The patent claims an applications programming interface that includes code libraries that enable transfer of pixel data, intermediate results data, or both, from a data structure or data file directly or indirectly to a user-provided application. The pixel data and intermediate results data may include data from biological experiments related probe arrays.

The Scan

Push Toward Approval

The Wall Street Journal reports the US Food and Drug Administration is under pressure to grant full approval to SARS-CoV-2 vaccines.

Deer Exposure

About 40 percent of deer in a handful of US states carry antibodies to SARS-CoV-2, according to Nature News.

Millions But Not Enough

NPR reports the US is set to send 110 million SARS-CoV-2 vaccine doses abroad, but that billions are needed.

PNAS Papers on CRISPR-Edited Cancer Models, Multiple Sclerosis Neuroinflammation, Parasitic Wasps

In PNAS this week: gene-editing approach for developing cancer models, role of extracellular proteins in multiple sclerosis, and more.