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BioArray Solutions, New York Blood Center, Euclid Diagnostics, Affymetrix

BioArray Solutions of Warren, NJ, and New York Blood Center of New York have received US Patent No. 7,449,295, “Method of nucleic acid typing for selecting registered donors for cross-matching to transfusion recipients.” The patent claims a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes — and the underlying combinations of alleles and haplotypes. The method described, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others. The genotypes are obtained by profiling specific markers in a hybridization-based assay.

Euclid Diagnostics of Crown Point, Ind., has received US Patent No. 7,449,297, “Methods of copying the methylation pattern of DNA during isothermal amplification and microarrays.” The patent claims a method for copying the methylation patterns in double-stranded DNA molecules during isothermal amplification of the DNA molecules by: a) obtaining DNA molecules; b) contacting the DNA molecules with transposable elements and an enzyme, which can randomly insert the transposable elements into the DNA molecules; and c) copying the methylation patterns of the DNA molecules using a DNA methylation-maintenance enzyme, while isothermally amplifying the DNA molecules using a DNA polymerase with strand displacement activity, under conditions that simultaneously promote activity of the DNA methylation-maintenance enzyme and the DNA polymerase. The patent also includes a buffer comprising a divalent ion, deoxynucleotide triphosphates, primers, and S-adenosyl-methionine; and a composition comprising a DNA methylation-maintenance enzyme, a DNA polymerase with strand displacement activity, and the buffer.

Affymetrix has received US Patent No. 7,451,047, “System and method for programmatic access to biological probe array data.” The patent claims an applications programming interface that includes code libraries that enable transfer of pixel data, intermediate results data, or both, from a data structure or data file directly or indirectly to a user-provided application. The pixel data and intermediate results data may include data from biological experiments related probe arrays.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.