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BioArray Solutions, Incyte, The University of North Carolina at Chapel Hill

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BioArray Solutions of Piscataway, NJ, has been awarded US Patent Number 6,387,707, "Array Cytometry." The patent describes a method in which biomolecules or colloidal particles are manipulated at the border of silicon oxide or another electrode and an electrolyte solution. The AC electric field induces assembly of planar aggregates, the electrolyte/silicon oxide/silicon interface exerts spatial control over the assembly process, and then external illumination is used to control the assembly process. These operations are designed for control of the creation of planar arrays that include several types of particles, and for sample preparation and handling for diagnostic assays and biochemical analysis. The patent also provides for the fabrication of surface-mounted optical components, and a method to direct the lateral motion and induce the assembly of cells on semiconductor surfaces into planar arrays.

Incyte has received US Patent Number 6,387,631, "Polymer coated surfaces for microarray applications." The invention provides methods for modifying a solid support so it becomes a substrate for microarrays. The modification involves silylating with agent with the formula H2N— (CH2)n — SiX3 where n is between 1 and 10, and X is independently chosen from OMe, OEt, Cl, Br, or I. Then the surface is activated with a crosslinking agent and reacted with an amine-containing polymer, and can be reacted with a crosslinking reagent a second time.

The University of North Carolina at Chapel Hill has received US Patent Number 6,387,625, "Monolayer and electrode for detecting a label-bearing target and method of use thereof." The patent covers an invention by UNC professor Holden Thorp, who is collaborating with Duke chemistry professor Michael Pirrung on a project with Xanthon to develop ultra-high-density oligonucleotide arrays. This patent describes an electrode that detects the interactions between members of a binding pair and can be used to detect nucleic acids as well as ligands, antigens, antibodies, and receptors. The electrode has been modified through the formation of a self-assembled monolayer. An oligonucleotide probe is coupled to this self-assembled monolayer. When a target nucleic acid hybridizes to this probe on the surface it is reacted with a transition metal complex that can oxidize a preselected base in an oxidation-reduction reaction. This reaction is detected as a means for detecting the target nucleic acid.

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