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BioArray Funding Update: Recent NSF Awards in Microarray Technology

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Innovative Protein Microarrays
Start Date:
Date: July 1, 2002
Expires: December 31, 2002
Estimated total amount: $99,978
Investigator: Andrzej K. Drukier
Sponsor: BioTraces

Small Business Innovation Phase I project to perform quantitation of proteins on antibody arrays using a method known as Multi Photon Detection technique (MPD). The company plans to initially create a cytokine array, and aim “to create an immunoassay based protein chip for the concurrent measurement of all the cytokines down to the level of a few zeptomole/ sample, to implement improved P-chip designs using peptide nucleic acid linkers, and to study the levels of cytokines in cell cultures and human samples.” Using the arrays, the company, based in Herndon, Va., hopes to correlate protein expression patterns with disease states.

• Patterned Substrates for Biochips
Start Date: July 1, 2002
Expires: December 31, 2002
Estimated total amount: $100,000
Investigator: Anoop Agrawal
Sponsor: ENKI

The goal of this Small Business Innovation Research Phase 1 Project is to develop microarrays for genomics and diagnostics made of sol-gel coatings and microstructures. The substrate, according to the grant award, “will allow higher density arrays and higher signal/noise ratio from each of the array elements.” ENKI, of Tucson, Ariz., plans to develop the microarrays for use in agriculture and healthcare.

The Scan

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In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.