BioArray Backgrounder: How RNAi and siRNA Work | GenomeWeb

The technology of RNAi triggers a natural gene silencing process that occurs when a virus invades a cell. As many viruses have double-stranded RNA, the cell has a built-in mechanism to attack this RNA: As double-stranded RNA enters the cell, an enzyme called Dicer chops it up into short 21-25 base-pair segments (called siRNA, for short interfering RNA or silencing RNA), which then combine with another group of enzymes to form a complex called RISC, or RNA-induced silencing complex.

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