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BASF-LYNX Bioscience, Motorola


BASF-LYNX Bioscience of Heidelberg, Germany, a joint venture between BASF chemicals and bead array maker Lynx Therapeutics of Hayward, Calif., has received German Patent Number DE0010049589A1, “Process for Mutation Analysis.” The invention covered pertains to a process for the analysis of sequence differences between nucleic acid molecules from a first and second group comprising the following steps: (a) Formation of heterohybrids; (b) if necessary, separation of homohybrids; (c) shortening of nucleic acid molecules from the first group of a heterohybrid with the help of double strand-specific exonuclease; and (d) discrimination between heterohybrids containing mismatches of one or more bases at the 3’ terminus of the nucleic acid molecule from the first group, the mismatched heterohybrids, and heterohybrids matching perfectly in that area.


Motorola has received US Patent Number 6,372,813, “Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays.” This patent describes polymer hydrogels on a solid support such as glass, which are designed to provide substrates for the attachment of biomolecules. The patent also describes the biomolecules with reactive sites that attach to the supports and the polymer hydrogels, as well as compositons and methods for preparing the biomolecules, supports, and hydrogels. One of these methods involves the crosslinking of supports and hydrogelsas well as the attachment of biomolecules the reactive sites in a photocycloaddition reaction: This can be accomplished in one step.

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