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Bacus Research Laboratories, NGK Insulators, The Regents of the University of California

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Bacus Research Laboratories of Lombard, Ill., received US Patent No. 6,466,690, “Method and apparatus for processing an image of a tissue sample microarray.” The patent covers a method and apparatus for processing an image of a tissue sample microarray and placing tissue samples in an array on a microscope slide. Images of the tissue are captured and stored together with identifying information. The images may be displayed from the digital storage medium that can select various magnifications for display.

NGK Insulators of Nagoya, Japan, received US Patent No. 6,465,190, “Method for producing DNA chip.” The patent covers the production of a DNA chip that makes it possible to improve the efficiency of the use of an expensive sample solution, improve the productivity of the DNA chip, and improve the yield, using a sample solution supplied by an ink-jet stream. It includes a pretreatment step of forming a poly-L-lysine layer on a surface of a base plate, a DNA sample preparation step, a DNA sample dilution step, and a supply step for supplying sample onto the base plate to produce a DNA chip. The sample preparation step includes a PCR-amplifying-step of the DNA fragment to prepare a PCR product, a powder formation step of drying the obtained PCR product to form DNA powder, and a mixing step of dissolving the obtained DNA powder in a buffer solution.

The Regents of the University of California received US Patent No. 6,465,182, “Comparative fluorescence hybridization to oligonucleotide microarrays.” The patent is for a method of determining the relative copy number of target nucleic acid sequences and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acid sequences immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acid sequences is hybridized. The hybridization of the labeled nucleic acid sequences to the solid surface is then detected using standard techniques.

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