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Aviva Biosciences, EI du Pont de Nemours, Narayan Baidya, Affymetrix, Purdue Research Foundation


Aviva Biosciences of San Diego received US Patent No. 6,716,642, “Individually addressable micro-electromagnetic unit array chips in horizontal configurations.” The patent covers a system of electromagnetic biochips with arrays of individually addressable micro-electromagnetic units for the direct manipulation of microparticles and structures.

EI du Pont de Nemours of Wilmington, Del., received US Patent No. 6,716,582, “Cellular arrays for the identification of altered gene expression.” The patent covers the generation and use of cellular arrays of microbial strains, which can be used in combination with other genome-registered arrays for functional analysis. Each strain comprises one reporter gene fusion made up of a gene or gene fragment operably linked to a reporter gene. Each gene or gene fragment has been “registered” or mapped to a specific location in the genome of the organism. The genome-registered collection of the device may be used to determine alterations in gene expression under a variety of conditions. Such collections are amenable to rapid assay and may be used to confirm, correct or augment data generated from DNA microarray technology.

Narayan Baidya, et al, received US Patent No. 6,716,579, “Gene specific arrays, preparation and use.” The patent covers a system of arrays of polynucleotide probes with sequences complementary to the 3’ untranslated region of a gene transcript, whose chromosomal location has been defined. The scheme includes a method of preparing the arrays and various methods of using them for detecting differential expression of multiple gene transcripts amongst multiple subjects.

Affymetrix received US Patent No. 6,715,500, “Cartridge washing system and methods.” A washing system comprises a support for holding several cartridges. Each cartridge has a chamber with an inlet and an outlet. Wash blocks are movably coupled to the support, each having two needles for penetrating the inlet and the outlet of a respective cartridge when the wash blocks are moved towards the support. Tubing is coupled to the needles for flowing liquid through the chamber of the cartridge.

Purdue Research Foundation received US Patent No. 6,716,620, “Biosensor and related method.” The patent covers a microscale biosensor for use in the detection of target biological substances — including molecules and cells. The technology includes a microfluidic system with integrated electronics, inlet-outlet ports and interface schemes for the detection of pathogens and the processing of biological materials at semiconductor interfaces. A fabrication process includes an all top-side processing for the formation of fluidic channels, planar fluidic interface ports, integrated metal electrodes for impedance measurements, and a glass cover sealing the non-planar topography of the chip.


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