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Autogenomics, Millipore, Agilent Technologies, Agilent, Eppendorf

Autogenomics of Carlsbad, Calif., has received European Patent No. 1770429, "Multi–substrate biochip unit." The patent claims an analytical device that contains a housing that encloses a multi-substrate chip with a reference marker and substrates. The housing is configured so that the reference marker and the substrates are illuminated by light sources at angles. Further described analytical devices include a housing with a cavity in it where a multi-substrate chip with a plurality of substrates is at least partially disposed. Additionally, at least one of the substrates is coupled to a carrier via a crosslinker that is disposed in a matrix.

Millipore of Billerica, Mass., has received European Patent No. 1772735, "Protein microarray slide." The patent claims a slide with a first and second surface on opposite sides of the slide where the slide has openings connecting the two surfaces and membranes mounted to a surface of the slide over the openings. The slide provides for both an ability to wash and to reduce the background fluorescence in the active membrane area, the patent's abstract states. Preferably the membrane is made of nitrocellulose, nylon, or polyvinylidene difluoride,. The openings can be used to allow wash solutions to pass through the membrane and be removed along with any contaminants from the slide, thereby reducing the fluorescent background. Additionally, the openings on the slide exhibit a lower fluorescence than a membrane that is laid over or attached to the slide, as neither the slide material or any adhesive is present which could increase the background.

Agilent Technologies has received US Patent No. 7,205,045, "Devices for calibrating optical scanners and methods of using the same." The patent claims calibration devices for optical scanners and methods for their use. The devices are characterized by having a polymeric coating with at least one fluorescent agent, where the devices have minimal local and global nonuniformities. The device may also include one or more photobleached regions. In using the devices, a surface is illuminated with at least one light source, fluorescence data is obtained from the surface, and the optical system is calibrated based upon the obtained fluorescence data. The described device finds use in a variety of optical scanners, including biopolymeric array optical scanners, the patent's abstract states.

Agilent has also received US Patents No. 7,206,438 and 7,206,439, both titled "Feature locations in array reading." The '438 patentclaims a method of processing one or more detected signal images, each acquired from a field of view of a chemical array reader. A location correction is then determined based on different detected signals at different image regions that represent regions in the field of view having the same actual signal. Alternatively, a location correction is applied to a detected signal at an image region. The location correction reduces detected signal discrepancy between different regions in an acquired image that represent different regions in the field of view having the same actual signal. An array reading system and computer program products are also described in the '438 patent.
The '439 patentdescribes a method by which feature locations are determined in an array image obtained from reading a chemical array. The chemical array comprises multiple features arranged in a polygon which optionally include sub-arrays within the array, according to the patent's abtract. According to the method, the complete image of the array or a sub-array is presented on a display. Magnified images of corner regions of the displayed complete image are simultaneously presented on the display with the complete image. A user selection of corners for the array or sub-array is then received and an array or sub-array outline is generated by linearly connecting the user selected corners. The generated actual outline is presented on the magnified image and may also be simultaneously presented on the complete image. Feature locations in the array or sub-array image may be then determined based on the actual outline.

Eppendorf Array Technology of Namur, Belgium, has received US Patent No. 7,205,104, "Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays." The patent claims a method for identifying or quantifying an organism by detecting its nucleotide sequence among at least four other homologous sequences. The sequences comprise amplifying nucleic acids from the organism and generate target nucleotide sequences to be detected. The target nucleotide sequences are then contacted with single-stranded capture nucleotide sequences bound by a single predetermined link to an insoluble solid support at a specific location on an array having a density of at least four different bound single-stranded capture nucleotide sequences. The location of the signal on the array allows identification or quantification of the organism.

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