Aspira Biosystems of San Francisco has received US Patent No. 6,458,599, “Compositions and methods for capturing, isolating, detecting, analyzing and quantifying macromolecules.” The patent claims broad methods of making imprint compositions capable of capturing macromolecules of interest. The invention encompasses solidifying a fluidic material, such as a mixture of polymers, which form shaped cavities in the presence of a template molecule that corresponds to a portion of the macromolecule. Once the polymers are solidified, the template molecules are removed, producing cavities that are capable of capturing the target macromolecule. Under the trade name ProteinPrint, Aspira is applying this technology to make arrays of protein capture agents for detecting specific proteins in biological samples.
Genzyme Molecular Oncology of Framingham, Mass., has received Japanese Patent No. 3,334,806. According to the company, the patent covers the methodology by which SAGE (Serial Analysis of Gene Expression) identifies and measures gene expression. Genzyme received a US patent covering SAGE in 1997.