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Applied Precision, Microchips, University of California, Agilent Technologies

Applied Precision of Issaquah, Wash., has received US Patent No. 7,408,176, “System and method employing photokinetic techniques in cell biology imaging applications.” The patent claims a system and method employing photokinetic techniques in cell biology imaging applications. The methods of acquiring image data include: a) selectively inducing photoactivation of material at a site on the object; b) performing an optical axis integration scan; c) simultaneously executing a time delay integration scan sequence; and d) processing acquired image data in accordance with one or more desired analyses. Potential applications may include multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.

Microchips of Bedford, Mass., has received US Patent No. 7,410,616, “Device for the controlled exposure of reservoir-based sensors.” The patent claims devices for the controlled exposure of a sensor or sensor component. The device includes a substrate; at least one reservoir provided in the substrate; at least one sensor or sensor component located in the at least one reservoir; at least one reservoir cap closing an opening in the at least one reservoir to isolate the sensor or sensor component from a selected environmental component outside of the at least one reservoir; at least one intermediate barrier layer disposed in the at least one reservoir between the reservoir cap and the sensor or sensor component; and means for disintegrating the reservoir cap to expose the sensor or sensor component to the selected environmental component.

The University of California of Oakland has received US Patent No. 7,410,803,
“Method and apparatus for preparing lipidic mesophase material.” The patent claims a method of dispensing a substance comprising lipidic cubic phases by: a) mixing the substance in a first syringe; b) coupling the first syringe with a second, smaller syringe; transferring the substance from the first syringe to the second syringe; decoupling the second syringe from the first syringe so as to permit manipulation of the second syringe; and then utilizing the second syringe to dispense the substance onto a microarray.

Agilent Technologies has received US Patent No. 7,412,085, “Method of extracting locations of nucleic acid array features.” The patent claims methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. The systematic errors are modeled by an algorithmic model based on measuring the positions and possibly other properties of a subset of the features, and a model is constructed for predicting deviations in feature position from an ideal grid. Deviations arising in the deposition process, the scanning process, or both may therefore be corrected.

The Scan

WHO Seeks Booster Pause

According to CNN, the World Health Organization is calling for a moratorium on administering SARS-CoV-2 vaccine boosters until more of the world has received initial doses.

For Those Long Legs

With its genome sequence and subsequent RNAi analyses, researchers have examined the genes that give long legs to daddy longlegs, New Scientist says.

September Plans

The New York Times reports that the US Food and Drug Administration is aiming for early September for full approval of the Pfizer-BioNTech SARS-CoV-2 vaccine.

Nucleic Acids Research Papers on Targeting DNA Damage Response, TSMiner, VarSAn

In Nucleic Acids Research this week: genetic changes affecting DNA damage response inhibitor response, "time-series miner" approach, and more.