Applera, the parent company of Applied Biosystems, received US Patent No. 6,649,404, "Method for using and making a fiber array." The patent covers an invention in which immobilized chemical species on a fiber are used to contact at least two chemical species. The fiber is placed on a support with a channel, and a mobile chemical species is sent into the channel so it contacts the fiber for detection. The patent also describes methods for analyzing contact between at least two chemical species, detecting their binding, making a microchip, and synthesis of the chemical species on a fiber.
The California Institute of Technology has received US Patent No. 6,649,350, "Electrochemical sensor using intercalative, redox-active moieties." The patent describes electrochemical detection and localization methods for genetic point mutations, as well as other common DNA lesions and perturbations within oligonucleotide duplexes, and their use in biosensing technologies. An intercalculative redox-active moiety is crosslinked or adhered to DNA that is immobilized on different separations from an electrode, and is probed in the presence or absence of a non-intercalculative redox-active moiety. The difference in electrical current, charge, or potential reflects interruptions in DNA-mediate electron transfer that are caused by mutations or other base-stacking perturbations.
NGK Insulators, Ltd. of Japan has received US Patent No. 6,649,343, “DNA chip and method for producing the same.” The chip is made by dripping solution onto a base plate to form a number of minute spots. The plate includes means for correcting deviations in spot position, which consist of at least one projection and one recess, as well as an electric field-generating means for providing charged states on the base plate.