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Applera, The California Institute of Technology, NGK Insulators, Ltd.


Applera, the parent company of Applied Biosystems, received US Patent No. 6,649,404, "Method for using and making a fiber array." The patent covers an invention in which immobilized chemical species on a fiber are used to contact at least two chemical species. The fiber is placed on a support with a channel, and a mobile chemical species is sent into the channel so it contacts the fiber for detection. The patent also describes methods for analyzing contact between at least two chemical species, detecting their binding, making a microchip, and synthesis of the chemical species on a fiber.

The California Institute of Technology has received US Patent No. 6,649,350, "Electrochemical sensor using intercalative, redox-active moieties." The patent describes electrochemical detection and localization methods for genetic point mutations, as well as other common DNA lesions and perturbations within oligonucleotide duplexes, and their use in biosensing technologies. An intercalculative redox-active moiety is crosslinked or adhered to DNA that is immobilized on different separations from an electrode, and is probed in the presence or absence of a non-intercalculative redox-active moiety. The difference in electrical current, charge, or potential reflects interruptions in DNA-mediate electron transfer that are caused by mutations or other base-stacking perturbations.

NGK Insulators, Ltd. of Japan has received US Patent No. 6,649,343, “DNA chip and method for producing the same.” The chip is made by dripping solution onto a base plate to form a number of minute spots. The plate includes means for correcting deviations in spot position, which consist of at least one projection and one recess, as well as an electric field-generating means for providing charged states on the base plate.


The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.