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Amersham Biosciences, Roche

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Amersham Biosciences has launched its CodeLink Human P450 SNP Bioarray. The company expects drug makers to use the chip when screening clinical trial populations for individuals’ toxicogenomic profiles. Amersham also said the chip may be used to determine new phenotypes linked to P450 mutation. The chip genotypes 110 SNPs within nine P450 drug metabolism genes — CYP1A1, 1A2, 1B1, 2C9, 2C19, 2D6, 2E, 3A4, and 3A5. The release comes around three months after Roche launched its own cytochrome P450 product, called Amplichip. This product is the subject of a letter issued by the US Food and Drug Administration in July questioning why Roche had marketed the Amplichip as an analyte-specific reagent.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.