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Amersham Biosciences, Cell Engineering, SIRS-Lab, NuGEN Technologies, Isenseit, Affymetrix

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Amersham Biosciences introduced the CodeLink UniSet Human 20K I Bioarray, a 19,000 human gene product for its CodeLink microarrays, last week and introduced a kit for sample preparation.

 

Cell Engineering, a spinout of the Wales College of Medicine, last week announced the introduction of Slam, a line of micro-pipette products that use a lipid coating as a novel method for cell manipulation. The technology, developed in 1998 by the surgery department at the university, consists of coating pipettes with lipids, which, the company said, improve on micro-injection methods that damage cells through the stab of the micro-pipettes. The new products now being launched by CE consist of glass or quartz micro-pipettes that are capped with lipids that fuse with the lipid bilayer of the plasma membrane of the cell on contact. This permits material to be transferred from the micro-pipette to the cell interior or from the lipid cap of a micro-rod to the cell membrane without the cell being penetrated. As only a touch, not a “stab,” is required to gain access to the cell interior, there is no damage to the cell. The company has licensed the technology, which is patented by Wales College of Medicine, and is backed by the Wales Spinout program of the Welsh Development Agency, and equity held by the school, the researchers and venture investors.

 

SIRS-Lab of Jena, Germany, introduced four Lab-Arraytor human 60 biochips at BioAnalytika in Munich recently. The low- to mid-density chips have increased specificity, which has been achieved through optimization of length, specific GC-content and the melting point of the probes used. SIRS-Lab was spun out of Friedrich Schiller University and the Hans Knoll Institute of Jena.

 

NuGEN Technologies of San Carlos, Calif., introduced the Ovation Nanosample RNA Amplification System for gene expression profiling on commercial and self-spotted oligo and cDNA microarrays. The product can amplify from samples as small as 5 nanograms.

 

Isenseit of Germany will introduce iQconvert, a program that translates Affymetrix platform data into *.csy format, the company said. The product will become a component in the company’s iQmega suite.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.