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Alan Higgins, Faye O Brien, Vincent Andaloro, James Bergey, Frank Guarnieri, Francis Brown


Alan Higgins has joined Paradigm Genetics of Research Triangle Park, NC, as senior director, investiga-tional medicine, and Faye O’Brien joined as senior director, healthcare marketing, the company said last week. Higgins was senior director, pharmacology, for Nobex, and had held positions with Oncogene Science, Hoffman-La Roche, and Pfizer Central Research. O’Brien was senior director, product management and marketing, for Gene Logic. Previously, she worked with Centocor - Johnson & Johnson, Amgen, and Boehringer Mannheim Pharmaceuticals.


Vincent Andaloro was named clinical site director of the MDS Pharma Services early clinical research facility in Phoenix, Ariz. Andalor previously was director of method development and validation at the company’s facility in Lincoln, Neb.


James Bergey was appointed vice president of business development, and Frank Guarnieri was named principal founding scientist for Locus Pharmaceuticals of Blue Bell, Pa. Bergey previously was vice president of business development for NeoPharm. He has worked with Inkine Pharmaceutical, and Bristol-Myers Squibb. Guarnieri previously was group head of biophysics and bioinformatics with Sarnoff.


Francis Brown was named senior vice president of sales and marketing for Celgene. Previously he held a number of executive positions for Pharmacia.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.