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Aisin Seiki Kabushiki Kaisha, Jena-Optronik, Clinical Micro Sensors


Aisin Seiki Kabushiki Kaisha of Kariya, Japan, earned US Patent No. 6,541,227, “Preparation of labeled DNA.” The patent covers a system for the preparation of labeled DNA, using a complex triple-stranded DNA through an deoxyoligonucleotide complementary to the deoxyoligonucleotide sequence of the 3’ terminal sequence of a double-stranded DNA, followed by replacement of the 3’ terminal region of the plus strand of the double-stranded DNA with at least one labeled dNTP. The system also includes a method to immobilize the prepared DNA onto a solid support.


Jena-Optronik of Jena, Germany, received US Patent No. 6,542,241, “Arrangement for optically reading out the information from substrates having a multiplicity of individual samples.” The patent covers a system for optically gathering information from radiation emitting from matrixed substrates containing individual samples. The system contains pixels reporting electronically to a receiver.


Clinical Micro Sensors of Pasadena, Calif., received US Patent No. 6,541,617, “Detection of target analytes using particles and electrodes.” The patent covers a biochip using binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence, or absence, of the target analyte to be determined.

The Scan

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Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.