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Agilix, Yale University, Nanosphere, Corning, The National Research Council of Canada, Fraunhofer-Gesellschaft


New Haven, Conn.-based Agilix and Yale University received US Patent No. 6,677,121, “Fixed address analysis of sequence tags.” The patent covers a method for the detection and analysis of nucleic acid samples. The method, referred to as Fixed Address Analysis of Sequence Tags (FAAST), involves the generation of a set of nucleic acid fragments having a variety of sticky-end sequences; indexing of the fragments into sets based on the sequence of sticky ends; associating a detector sequence with the fragments; sequence-based capture of the indexed fragments on a detector array; and detection of the fragment labels. Generation of the multiple sticky end sequences is accomplished by incubating the nucleic acid sample with one or more nucleic acid cleaving reagents. The indexed fragments are captured by hybridization and coupling, preferably by ligation, to a probe. The method allows a complex sample of nucleic acid to be quickly and easily cataloged in a reproducible and sequence-specific manner. One form of the method allows determination of associations, in a nucleic acid molecule, of different combinations of known or potential sequences. Another form of the method assesses modification of sequences in nucleic acid molecules by basing cleavage of the molecules on the presence or absence of modification.

Nanosphere of Northbrook, Ill., received US Patent No. 6,677,122, “Nanoparticles having oligonucleotides attached thereto and uses therefore.” The patent covers methods for detecting nucleic acids by contact with particles having oligonucleotides attached. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention system provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

Corning received US Patent No. 6,677,131, “Well frame including connectors for biological fluids.” The patent covers a system and method for hybridization reactions between molecules. The technology includes a hybridization chamber with a planar substrate that has a specimen area containing one or more molecules and a frame surrounding at least a portion of that area, which defines a well for holding a fluid. In the frame is a connector adapted to connect to tubing for supplying fluids to the well.

The National Research Council of Canada received US Patent No. 6,677,163, “Functionalized silicon surfaces, and method for their production.” The patent covers a method for modifying silicon with an organic molecule, under mild conditions. If the attached molecule is bi-functional, it may be subsequently reacted with a biomolecule, to form a covalently attached layer on a silicon surface.

Fraunhofer-Gesellschaft of Munich, Germany, received US Patent No. 6,677,132, “Device and method for monitoring and controlling biologically active fluids.” The patent covers a method for determining the concentration of organisms in a fluid, where metabolite parameters are recorded by means of a data acquisition unit and subsequently converted.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.