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Agilent Technologies, Ut-Battele, Rensselaer Polytechnic Institute, Regents of the University of California, Affymetrix

Agilent Technologies has received US Patent No. 7,266,473, “Fast microarray expression data analysis method for network exploration.” The patent describes a method for feature selection by: a) selecting a predictor set of features; b) adding at least one complementary feature to the predictor set based on a quality of prediction; and c) checking to see if all of the features of the predictor set are repeated, and if not, removing at least one feature from the predictor set. The algorithm and method repeats the steps of adding complements, checking the predictor set and removing features until the features of the predictor set are repeated. Once the features of the predictor set are repeated the proper number of times, the algorithm and method terminate.

Agilent has also received US Patent No. 7,269,518, “Chemical array reading.” The patent claims a method of reading a chemical array on an array reader, where the chemical array is exposed to a sample, and the results of the reading are saved in a memory. The saved results are then linked with a performance characteristic of the array reader, and the saved results are processed using the linked performance characteristic of the reader.

Ut-Battele of Oak Ridge, Tenn., has received US Patent No. 7,267,948, “SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips.” The patent describes Raman and SERS assay methods and systems including microarrays, biosensors and biochips for the detection of biotargets such as DNA, proteins and pathogens using receptor probes. The receptor probes may include one or more bioreceptors selected from antibodies, DNA, enzymes, tissues, organelles, as well as other receptor probes, and combinations of each

Rensselaer Polytechnic Institute of Troy, NY, and the Regents of the University of California of Oakland, Calif., have received US Patent No. 7,267,958, “Biocatalytic solgel microarrays.” The patent claims a system and method for conducting high-throughput interactions between test compositions and analytes. It also describes an apparatus comprising: a) a solid support; and b) a plurality of independent, micromatrices. The micromatrices have a) a volume of less than about one microliter; b) encapsulate at least one test composition comprising a protein; c) are not separated from each other by a physical barrier; d) are substantially impermeable to the test composition; and e) are permeable to an applied composition comprising a constituent that has potential for reaction with the test composition.

Affymetrix has received US Patent No. 7,267,966, “Complexity management and analysis of genomic DNA.” The patent describes methods of sample preparation and analysis involving reproducibly reducing the complexity of a nucleic sample. It also provides methods for analysis of the sample by hybridization to an array which may be specifically designed to interrogate the desired fragments for particular characteristics, such as, for example, the presence or absence of a polymorphism. Additional methods are claimed for using a computer system to model enzymatic reactions in order to determine experimental conditions before conducting actual experiments.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.