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Agilent Technologies, The University of Oregon, Corning, Olympus

Agilent Technologies has received US Patent No. 7,141,368, “Multi-directional deposition in array fabrication.” The patent claims a method, an apparatus, and computer program products for fabricating multiple chemical arrays on a substrate. Each array fabricated has multiple rows of feature locations with arrays of different sets being arranged in a sideways orientation with respect to the rows, according to the patent’s abstract. The method includes dispensing drops from a drop dispensing head onto the substrate while maintaining a gap between the head and substrate and moving them relative to one another along a path so as to fabricate the arrays. The path for the relative moving includes moving the head in a direction along the rows of a first array set then moving the head in an opposite direction along the rows of a second array set. This pattern is repeated with the second array set of an earlier cycle being the first array set of a later cycle, the abstract states.

The University of Oregon in Eugene has received US Patent No. 7,141,371, “Methods for detecting and localizing DNA mutations by microarray.” The patent claims methods for detecting and localizing DNA mutations by DNA microarray. The described methods include the use of restriction endonucleases or mismatch-recognition nucleases to detect and localize mutations. In one method, reference and target DNA are digested using one or more restriction endonucleases. The resultant DNA strands are then labeled, and the labeled mixture of DNAs is hybridized to a microarray. In another method, reference and target DNA are denatured and annealed to form a mixture containing heteroduplex DNA. One or more mismatch-recognition nucleases are then used to nick or cleave at least a portion of the heteroduplex DNA, and resultant DNA strands are labeled.

Corning has received US Patent No. 7,141,374, “Treatment of substrates for immobilizing biomolecules.” The patent claims a method of treating a substrate for immobilizing a biomolecule and producing substrates. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent then substantially eliminates autofluorescence on the produced substrates.

Olympusof Tokyo has received US Patent No. 7,141,802, “Optical device and imaging method.” The patent claims an optical device that includes 1) a carrier that holds a specimen and has a reference mark; 2) an image capturing means that picks up the image of the specimen and the reference mark formed by an objective lens; 3) a moving mechanism that moves the relative positional relation between the carrier and the objective lens and divides the imaging region into a plurality of regions so that adjacent regions partially overlap each other to enable the image of the specimen and the reference mark in each region to be captured by the image capturing means; 4) and an image processing section that composites images of the plurality of regions captured by the image capturing means to match the same reference marks appearing on the overlapping portions.

The Scan

US Booster Eligibility Decision

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Additional Genes

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Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.