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Agilent Technologies, Surface Logix, PerkinElmer

Agilent Technologies has received US Patent No. 7,437,249, “Methods and systems for detrending signal intensity data from chemical arrays.” The patent claims methods, systems, and computer-readable media for removing trends in signal intensity values from features on a chemical array. The methods include: a) inputting signal intensity values from all features on the array after filtering to remove at least one of saturated features, non-uniform features and control features; b) calculating a log transform of each signal intensity value inputted to provide log signal intensity values; c) calculating a surface approximation of the log signal intensity values; d) normalizing surface fit values on the calculated surface approximation in locations corresponding to locations of the features on the array from which signal intensity values were inputted; e) calculating a reverse-log transform of the normalized surface fit values; f) de-trending the inputted signal intensity values as a function of the normalized surface values in locations corresponding to the locations of the features from which the signal intensity values were inputted; and g) outputting de-trended signal intensity values.

Surface Logix of Brighton, Mass., has received US Patent No. 7,439,056, “Peelable and resealable devices for arraying materials.” The patent describes a device for arraying a biological material comprising: a) a base plate; b) a first removable member in self-sealing contact with the base that contains a first array; c) a second removable member in self-sealing contact defining a second array; and d) at least one registration element adapted to align the base plate, the first removable member, and the second removable member with one another.

PerkinElmer of Waltham, Mass., has received US Patent No. 7,439,346, “Nucleic acids arrays and methods of use therefor.” The patent claims compilations of nucleic acids, methods of depositing the nucleic acids on substrates, and methods of use of the compilations and arrays for the detection of chromosomal disorders, such as chromosomal aneuploidies, deletions, amplifications, and diagnosis and prognosis of syndromes associated with a contiguous gene abnormality. Specifically, microarrays are described that contain cloned genomic nucleic acids immobilized on the surface at discrete and known spots, where a first set of spots having nucleic acids associated with the chromosomal disorder and a second set of spots having control nucleic acids for the chromosome are present.

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.