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Agilent Technologies, Sensorchem International, Eppendorf, General Electric

Agilent Technologies has received US Patent No. 7,101,508, “Chemical array fabrication errors.” The patent claims a method of fabricating an array of chemical probes at feature locations on a substrate surface. The method uses a deposition apparatus with a substrate unit that provides the probes on the substrate surface in the target array pattern. A fiducial and a deposited drop are arrayed on the substrate unit so that the actual position of the deposited drop may be determined in relation to the fiducial on the substrate unit. An error can then be determined based on any difference between the actual and target positions. The apparatus for fabricating the array as well as computer program products are also claimed.

Sensorchem International of Toronto has received US Patent No. 7,101,669, “Enzyme-based regeneration of surface-attached nucleic acids.” The patent claims a process for the regeneration of a microarray through enzymatic digestion of a target from a surface-attached probe. According to the patent’s abstract, the probe uses a nuclease to digest a single strand of a nucleic acid duplex with directional specificity starting from the free end of the target strand. Once the target strand is digested, the enzyme is rinsed from the microarray. The microarray is then considered regenerated and ready for subsequent use.

Eppendorf has received US Patent No. 7,102,131, “Device for photometric measurement of several samples.” The patent claims a device for the photometric measurement of several samples that are exposed to radiation from a light source. According to the patent’s abstract, the light modified by the samples is intercepted by an optical device and is guided as a sum of all the light radiated from all samples to at least one sensor for measuring the intensity and evaluation. The light sources are controlled individually by a control device and the evaluation device and the control device are controlled so that the evaluation device separates the light from each sample from the light of the other samples. According to the patent, the apparatus can be used to test a plurality of microarray spots on glass slides.

General Electric of Niskayuna, NY, has received US Patent No. 7,102,158, “Light-based system for detecting analytes.” The patent claims a device, kit, and method to detect analytes such as nucleic acids. According to the patent’s abstract, an excitation source, preferably a nitride-based LED, emits light capable of being absorbed by luminophores. Sensors are then attached to a surface within the device, such as the surface of the excitation source that is exposed to the sample. When a complex is formed between the sensors and the analyte, the luminophores emit light or emit light of a different wavelength, thereby signaling the presence or quantity of the analyte. According to the abstract, the excitation source, sensors, luminophores and other features of embodiments of the invention may be present as discrete elements or as a microarray or nanoarray of elements.

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.