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Agilent Technologies, Nanogen, Invitrogen


Agilent Technologies received US Patent No. 6,591,196, “Method and system for extracting data from surface array deposited features.” The patent covers a method for extracting data signals from a scanned image of a molecular array. The positions of corner features are first located. Then, an initial feature coordinate grid is determined from the positions of the corner features. A refined feature coordinate grid is then calculated, based on the positions of strong features, and is used to iden-tify the positions of weak features and the positions of the local background regions. Finally, signal intensity values are extracted from the features and local background regions in the scanned image, and background-subtracted signal intensity values, background-subtracted and normalized signal intensity ratios, and variability information and confidence intervals are determined based on the extracted values.

The Palo Alto, Calif.-based company also received US Patent No. 6,589,739, “Biopolymer array inspection.” The patent covers a method and an apparatus for fabricating a biopolymer array. Light is directed through the substrate from the front side, back through a substrate on the back side, and a first set of deposited droplets on the first side, to an image sensor. The substrate may be mounted by means of a chuck with parallel channels, and a scanning operation of a droplet dispensing head, light source, and sensor conducted in unison in the direction of the channels.


Nanogen received US Patent No. 6,589,742, “Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures.” The patent covers a method for amplifying nuc-leic acids where detection of amplified species is enhanced by the use of amplification made assymetric by using divergent ratios of amplification primers or by using non-extending and/or non-cleavable amplification primers. Detection of the amplicons is improved because maintenance of single-stranded species of amplicons during amplification facilitates their direct capture by immobilized probes without denaturing steps.


Invitrogen received US Patent No. 6,589,737, “Compos-itions and methods for labeling of nucleic acid molecules.” The patent covers methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases.

The Scan

US Booster Eligibility Decision

The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions.

Arizona Bill Before Judge

The Arizona Daily Star reports that a judge weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction.

Additional Genes

Wales is rolling out new genetic testing service for cancer patients, according to BBC News.

Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.