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Agilent Technologies, Hitachi Software Engineering, Affymetrix, University of North Carolina


Agilent Technologies has received US Patent No. 6,994,429, "Printhead fluid supply system." The patent claims a printhead fluid supply system for use in ink-jet or pulse-jet type printers. According to the patent, a nanometer feature may be used as a pressure gauge to maintain desired pressure at a printhead. Additional features that may be used include a supply tubing setup configured to avoid introduction of air into a printhead as well as a system to replenish the printing fluid supply while the system is running. The patent states that the system may be used in ink-jet or pulsejet printing systems, such as those used in document production or in more specialized applications such as microarray production.

Hitachi Software Engineering of Kanagawa, Japan, has received US Patent No. 6,994,965, "Method for displaying results of hybridization experiment." The patent claims a method for verifying the accuracy of hybridization experiments in which a plurality of probe biopolymers are hybridized to sample biopolymers, and information concerning the hybridization level for each of the probe biopolymers obtained from the hybridization experiment is displayed together with similarity scores representing the similarities between base sequences of the probe biopolymers. The patent claims that by comparing the two, it is possible to visually confirm whether a probe biopolymer with a similar base sequence to that of an object probe biopolymer has a similar hybridization level. According to the patent, any unexpected hybridization reactions can then be identified.

Affymetrix has received US Patent No. 6,996,475, "Computer software products for nucleic acid hybridization analysis." The patent describes methods and computer software for determining hybridization between a plurality of nucleic acid probes and a nucleic acid target. Specifically, the hybridization intensities of each probe are adjusted by dividing the intensities by the affinities of the probes and the minimal adjusted hybridization intensity may be used as the measurement of the gene expression. According to the patent's abstract, the methods are useful for analyzing any hybridization between multiple probes and a target nucleic acid but can also be used for single transcript as determined using multiple probes.

University of North Carolina of Charlotte has received US Patent No. 6,996,476, "Methods and systems for gene expression array analysis." The patent claims methods and systems for applying independent component analysis and other signal processing techniques to identify an optimal number of independent gene clusters and to separate gene expression data into biologically relevant groups. An interface that allows the user to review the results at various stages during the analysis is also claimed.


The Scan

Not as High as Hoped

The Associated Press says initial results from a trial of CureVac's SARS-CoV-2 vaccine suggests low effectiveness in preventing COVID-19.

Finding Freshwater DNA

A new research project plans to use eDNA sampling to analyze freshwater rivers across the world, the Guardian reports.

Rise in Payments

Kaiser Health News investigates the rise of payments made by medical device companies to surgeons that could be in violation of anti-kickback laws.

Nature Papers Present Ginkgo Biloba Genome Assembly, Collection of Polygenic Indexes, More

In Nature this week: a nearly complete Ginkgo biloba genome assembly, polygenic indexes for dozens of phenotypes, and more.