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Agilent Technologies, Dermtech International, Decision Biomarkers, Affymetrix

Agilent Technologies has received US Patent No. 7,297,477, “Methods and compositions for detecting viral nucleic acid in a cell.” The patent claims methods and compositions for identifying or detecting viral nucleic acids in a host cell. DNA fragments are first bound to DNA-binding protein in a host cell and enriched using immunoprecipitation. The enriched fragments are then hybridized to a microarray containing sequences complementary to proviral DNA and genomic DNA.

Dermtech International of San Diego has received US Patent No. 7,297,480, “Method for detection of melanoma.” The patent describes non-invasive methods for detecting, monitoring, staging, and diagnosing malignant melanoma in a skin sample of a subject. The methods include analyzing expression in skin sample of one or more melanoma skin markers using a microarray. The skin sample can include nucleic acids, and can be a human skin sample from a lesion suspected of being melanoma.

Decision Biomarkers of Waltham, Mass., has received US Patent No. 7,297,497, “Substrates for isolating, reacting and microscopically analyzing materials.” The patent claims an immobilizing device for biological material that includes a substrate layer on a microscope slide, a round disc, a bio-cassette at the bottom of a well of a multi-well plate, and a coating inside a tube. Fluorescence or luminescence intensity and geometric calibration spots are shown and reading is enhanced by the intensity calibration spots.

Affymetrix has received US Patent No. 7,297,778, “Complexity management of genomic DNA.” The patent claims methods and kits for analyzing a collection of target sequences in a nucleic acid sample. First the sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. Then the sample is analyzed following hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.