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Agilent Technologies, Clinomics Biosciences, Zyomyx, Affymetrix, The Council of Scientific & Industrial Research


Agilent Technologies received US Patent No. 6,583,424, “Scanning system with calibrated detection and method.” The patent covers a microarray scanning system that is self-calibrating to compensate for sensitivity changes in the detection portion of the system and to help assure consistency in the accuracy of the instrument.

Clinomics Biosciences of Pittsfield, Mass., received US Patent No. 6,582,967, “Method of forming a microarray from frozen tissue.” The patent covers a device for constructing frozen tissue microarrays. The device comprises: a cooling chamber movable in a horizontal x and y direction for receiving frozen material and for maintaining the temperature; at least one coring needle; and at least one element for positioning the material for cutting. The patent also covers a system for generating frozen material from a number of different samples.

Zyomyx of Hayward, Calif., received US Patent No. 6,582,969, “Microdevices for high-throughput screening of biomolecules.” The patent covers a method for the parallel, in vitro, screening of biomolecules such
as protein, polypeptides, nucleic acids, polysaccharides, phospholipids, and polymers – using miniaturized
microfabricated devices. These devices are useful in high-throughput drug screening and clinical diagnostics and are used for the parallel screening of families of related proteins, the inventors said.

Affymetrix received US Patent No. 6,584,410, “Polymorphism detection utilizing clustering analysis.” The patent covers a system and method for detecting differences in sample polymers, such as nucleic acid sequences. Hybridization affinity information for the sample polymers is clustered so that the differences, if any, between or among the sample polymers can be readily identified. By clustering the hybridization affinity information of the sample polymers, differences in the sample polymers can be accurately achieved even in the presence of random and systematic errors.

The Council of Scientific & Industrial Research of New Delhi, India, received US Patent No. 6,582,730, “Natural fluorescent dye obtained from a marine invertebrate, compositions containing the said dye and their uses.” The patent covers a process of extraction, purification, and characterization of a fluorescent dye from a marine echinoderm Holothuria scabra, and compositions containing the dye, and various applications of the dye such as its use in labeling during the processes of microarray analysis.


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