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Agilent Technologies and Molecular Dynamics


Agilent Technologies of Palo Alto, Calif. has received US Patent Number 6,444,268, ”Functionalization of substrate surfaces with silane mixtures.” The invention provides functionalized surfaces on solid supports. A first silane provides a reduction in surface energy, while a second silane enables functionalization with molecular moieties of interest, such as small molecules, initial monomers to be used in the solid phase synthesis of oligomers, or intact oligomers.

Molecular Dynamics of Sunnyvale, Calif. has been awarded US Patent Number 6,444,423, ”Nucleosides comprising polydentate ligands.” The invention covers the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent new derivatives that are bimolecular templates capable of transferring electrons over large distances at fast rates. These complexes enable the use of a new class of bioconductors and diagnostic probes.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.