Agilent Technologies of Palo Alto, Calif. has received US Patent Number 6,444,268, ”Functionalization of substrate surfaces with silane mixtures.” The invention provides functionalized surfaces on solid supports. A first silane provides a reduction in surface energy, while a second silane enables functionalization with molecular moieties of interest, such as small molecules, initial monomers to be used in the solid phase synthesis of oligomers, or intact oligomers.
Molecular Dynamics of Sunnyvale, Calif. has been awarded US Patent Number 6,444,423, ”Nucleosides comprising polydentate ligands.” The invention covers the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent new derivatives that are bimolecular templates capable of transferring electrons over large distances at fast rates. These complexes enable the use of a new class of bioconductors and diagnostic probes.