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Agilent Technologies, Affymetrix, Canon Kabushiki Kaisha, Phenogene Therapeutiques


Agilent Technologies of Palo Alto, Calif., has received US Patent No. 6,832,163, “Methods of identifying heterogeneous features in an image of an array.” The patent covers methods for identifying heterogeneous features, including heterogeneous background regions, in an image of an array, e.g., in an image of a biopolymeric array, such as a nucleic acid array. The subject methods employ an algorithm that employs a different dispersity measure depending on whether the signal features are weaker or stronger. Also provided are computer-readable storage media that include an algorithm capable of performing the steps of the subject methods. The subject methods find use in the processing of images obtained from a variety of different types of arrays, including nucleic acid arrays.

Affymetrix of Santa Clara, Calif., has received US Patent No. 6,828,104, “Nucleic acid affinity columns.” The patent covers nucleic acid affinity matrices that bear a large number of different nucleic acid affinity ligands, allowing the simultaneous selection and removal of a large number of preselected nucleic acids from the sample. Methods of producing such affinity matrices are also provided in the patent.

Canon Kabushiki Kaisha of Tokyo has received US Patent No. 6,830,621, “Liquid discharge apparatus for producing probe carrier, apparatus for producing probe carrier and method for producing probe carrier.” The patent covers a liquid discharge apparatus for producing a probe carrier, having a configuration capable of supplying a discharge unit with plural probe solutions without increasing the dimensions of the apparatus. It also covers a method and apparatus for producing the probe carrier utilizing such a liquid discharge apparatus.

Phenogene Therapeutiques of Montreal has received US Patent No. 6,830,885, “Nucleic acid molecule, method and kit for selecting a nucleic acid having a desired feature.” The invention provides a dysfunctional viral genome capable of both expressing libraries of exogenous nucleic acids and selecting the sequences having a predefined characteristic or function within the cell, such as nucleic acids encoding signal peptides, secreted proteins, membrane bound proteins, proteases, and drug-resistance proteins. The patent also covers a method and a kit for selecting nucleic acids having a desired feature, wherein production of a viral particle is dependent on insertion of an exogenous nucleic acid having the desired feature into a dysfunctional viral genome or into a viral genome exposed to a substance inhibiting viral packaging function(s).

The Scan

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BBC News reports that COVAX is experiencing a vaccine shortfall, as the Serum Institute of India has paused exports.

Sanofi, GSK Report Promising Results

The Wall Street Journal reports that the candidate SARS-CoV-2 vaccine from Sanofi and GlaxoSmithKline has had encouraging early results.

Influence of Luck

The New York Times examines how the US avoided variant-fueled increases in COVID-19 cases.

PLOS Papers on Retina GWAS, Hantaan Virus, COVID-19 Phenome-Wide Association Study

In PLOS this week: genome-wide association study of retinal morphology, analysis of hantaan virus found in a mouse, and more.