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Affymetrix, Spectral Genomics, Genetix, SuperArray Bioscience


Affymetrix this week launched version 2.0 of its GeneChip Mapping 10K Array and the GeneChip Mapping 100K set. Both products utilize the same assay developed for the earlier GeneChip Mapping 10K Array and require one universal primer and a simple protocol, the company said. Pricing details were not disclosed.

Spectral Genomics of Houston this week introduced the Constitutional Chip BAC Clone Microarray for comparative genomic hybridization applications. The Constitutional array, containing 464 BAC clones associated with “constitutional” analysis of 41 known genetic syndromes and telomere abnormalities, is capable of detecting single-copy-number changes, the company said. The chip also includes spots representing negative controls, calibration controls for standardization of detection, and clones not likely to be affected by genetic defects that form the baseline for detection. Among the clones are those believed to be associated with common pre-natal and post-natal analysis of genetic defects based on established practices including, trisomy 21, trisomy 18, Wolf Hirshorn Syndrome, DiGeorge Syndrome, and Cri du Chat Syndrome.

Genetix announced a new blue laser option for its aQuire dual-laser scanner for use in the detection of GFP, fluorescein, and other fluorophores and for application in imaging DNA, protein, cell, and tissue microarrays. The laser is available for $22,000, the company said.

SuperArray Bioscience of Frederick, Md., this week launched two new arrays in its Oligo GEArray line of pathway specific DNA microarrays with content specific to human hematology and cancer.

The products use chemiluminescence detection and a one-tube labeling method and can be processed using basic molecular biology lab equipment. The arrays are constructed of customizable, 60-mer oligonucleotide probes, and sell for $100 each.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.