Affymetrix of Santa Clara, Calif., has received US Patent No. 6,813,567, “System, method, and product for dy-namic noise reduction in scanning of biological mater-ials.” The patent covers systems and methods for processing an emission signal, such as a fluorescent signal, to compensate for noise in an excitation beam, such as a laser beam. As one example, a scanning system is described that includes a generator that provides an excitation signal having one or more representative excitation values representative of an excitation beam; an excitation reference provider that provides at least one excitation reference value; a normalization factor generator that compares the excitation reference value to at least one representative excitation value, thereby generating a normalization factor; and a comparison processor that adjusts at least one emission value corresponding to at least one representative excitation value based, at least in part, on the normalization factor.
Santur of Fremont, Calif., has received US Patent No. 6,813,300, “Alignment of an on-chip modulator.” The patent covers one or more single-mode waveguide devices that are fiber-coupled such that signals to an optical element affect the coupling of the waveguide device to one or more on-chip modulators and to an optical fiber. The optical element or additional optical elements are controlled to adjust the coupling of the waveguide device to an on-chip modulator and to an optical fiber.
Illumina of San Diego, and The Regents of the University of California of La Jolla, Calif., have received US Patent No. 6,812,005, “Nucleic acid detection methods using universal priming.” The present invention is directed to providing sensitive and accurate assays for gene detection, genome-wide gene-expression profiling, and alternative splice monitoring with a minimum or absence of target-specific amplification.
The California Institute of Technology of Pasadena, Calif., has received US Patent No. 6, 811,977, “Rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping.” The patent covers methods of identifying one or more nucleic acids in a sample. The nucleic acids, for example, expressed genes in a cell, can be identified by contacting the nucleic acids with oligonucleotides having detector tags, and selector tags to form tagged oligonucleotides. Each nucleic acid can be uniquely identified by mass-spectrophotometric analysis of the detector tag.
The Regents of the University of California of Oakland, Calif., have received US Patent No. 6,811,973, “Methods of using labeled probe molecules to quantify target molecules.” The patent covers an assay system using labeled probe molecules to identify and quantify target molecules in a sample. Where labeled probe molecules are present on a substrate such as a microarray, the identification of multiple different target molecules may be examined simultaneously. Alternatively, a known number of like probe molecules may be present on a substrate and a single target molecule may be quantified in a sample. Preferred labeled probe molecules are comprised of fluorescent single-stranded nucleotide analogs whose fluorescence is quenched by pairing with a homologous nucleotide target sequence.