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Affymetrix, PerkinElmer, Ulrich Krull, Larry Gold, Incyte Genomics

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Affymetrix received US Patent No. 6,505,125, “Methods and computer software products for multiple probe gene expression analysis.” The patent covers a system of computer software for analyzing gene expression data determined by multiple probes in several experiments. A principal component analysis is performed to obtain the relative expression of the gene in these experiments. The signals are derived from hybridization between perfect match probes (PM), designed to be complementary to the target nucleic acid, and mismatch probes (MM), designed to contain at least one mismatch to the target nucleic acid. The signals are the hybridization intensity difference (PM-MM). A matrix is calculated to determine the principal components.

PerkinElmer received US Patent No. 6,503,716, “Compositions and methods for extracting a nucleic acid.” The technology provides aqueous compositions of sodium metasilicate and an ether used to extract a nucleic acid from a cell, virus, or other source. The extracted nucleic acids may include one or more reagents for making or using a DNA microarray.

Ulrich Krull of Mississauga, Ontario, Canada, received US Patent No. 6,503,711, “Nucleic acid biosensor diagnostics.” The patent covers a biosensor for direct analysis of nucleic acid hybridization by use of nucleic acid molecules immobilized onto the surface of optical fibers, and fluorescence transduction. Biotechnology applications include monitoring of gene cultures and gene expression and the effectiveness of gene therapy pharmaceuticals. The invention includes fluorescent biosensor systems. The preferred method for immobilization of nucleic acids is by in situ solid phase nucleic acid synthesis. Control of the refractive index of the immobilized nucleic acid is achieved by the support chemistry and the nucleic acid synthesis.

Larry Gold of Boulder, Colo., received US Patent No. 6,503,715, “Nucleic acid ligand diagnostic biochip.” This chip consists of a solid support to which one or more specific nucleic acid ligands are attached. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid. The biochip could be used to test any chemically complex mixture provided that nucleic acid ligands to components suspected of being present in the mixture are attached to the biochip.

Incyte Genomics received US Patent No. 6,503,708, “Microtubule-associated protein.” The invention provides a human microtubule-associated protein (HMAP) and polynucleotides which identify and encode HMAP. The oligonucleotides or longer fragments derived from any of the polynucleotide sequences may be used as targets in a microarray.

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