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Affymetrix, NextGen Sciences

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Affymetrix of Santa Clara, Calif., has received US Patent No. 6,480,324 “Methods involving direct write optical lithography.” The patent is for an improved optical photolithography system and method that provides predetermined light patterns generated by a direct write system without the use of photomasks. The system works on the surface of a substrate (e.g., a wafer) by using a computer controlled component for dynamically generating the predetermined light pattern, e.g., a spatial light modulator. Image patterns are stored in a computer and through electronic control directly illuminate the wafer to define a portion of the polymer array, rather than being defined by a pattern on a photomask.

NextGen Sciences of Huntingdon, Cambridgeshire, UK, was awarded UK Patent No. GB 237 0039, “Producing Protein Arrays and Fusion Proteins for use therein,” the company said. The patent covers a peptide-based fusion tag that can be biotinylated in vivo or in vitro at a single lysine residue within the tag sequence for the use in the production of protein chips. This enables the proteins to attached to streptavidin-coated protein biochip substrates in a predictable manner.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.