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Affymetrix, Nanogen, Nihon University

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Affymetrix has received US Patent No. 7,053,198, "Functionated photoacid generator and functionated polymer system for biological microarray synthesis." Methods are described for the synthesis of polymer arrays, including the steps of: a) coating a substrate with a reactive polymer matrix and a photo carboxylic acid generator; b) exposing the substrate with patterned radiation to remove acid labile protecting group in reaction areas; and d) coupling a monomer into the reaction areas. The reaction areas are then exposed to radiation to generate acids that the patent claims are for removing acid labile protecting groups. The steps can then be repeated to generate desired polymers in specific locations of the substrate.


Affymetrix has also received US Patent No. 7,053,206, "Methods and compositions for multiplex amplification of nucleic acids." The patent claims a method for predetermining ratios of primer pairs present in a single reaction vessel in order to achieve approximately an equimolar yield of products. The ratios are determined as a function of the length of the amplicon and the length of other amplicons being simultaneously tested. The primers may desirably be for p53 gene sequences, the patent states.


Nanogen of San Diego has received US Patent No. 7,045,097, "Biologic electrode array with integrated optical detector." The patent describes a biologic electrode array formed on a semiconductor substrate. A matrix of electrode sites is disposed on the semiconductor substrate and a matrix of optical detectors is disposed beneath the electrode sites in the semiconductor substrate, where each electrode site is associated with a corresponding optical detector. The optical detectors are coupled to detection circuitry formed on the semiconductor substrate and the electrode sites may include slitted electrodes, punctuated electrodes, or optically transparent electrodes, according to the patent.


Nihon University of Tokyo has received US Patent No. 7,052,835, "Method of screening a gene." The patent claims a method of screening genes based on expression information. The claimed method of screening genes comprises performing in situ hybridization in respect of a tissue or cell sample from an organism using a probe which hybridizes with mRNA and/or expression sequence tag, and examining localization of the mRNA and/or expression sequence tag in the tissue or cell.

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