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Affymetrix, MicroChips, Amersham Biosciences, Cartesian Technologies, Roche Diagnostics, Helix BioPharma


Affymetrix received US Patent No. 6,551,784, “Method of comparing nucleic acid sequences.” The patent covers a system for comparing and identifying differences in nucleic acid sequences and is an extension of the Santa Clara, Calif., company’s tract of intellectual property surrounding its methods of microarray analysis of gene expression. The company also received US Patent No. 6,551,817, “Method and apparatus for hybridization.” This patent covers a packaging system for a device containing probe molecules and methods for introducing fluids into it. The company also received US Patent No. 6,551,784, “Method of comparing nucleic acid sequences.” The patent covers a computer-implemented method for monitoring expression of genes.


MicroChips of Bedford, Mass., received US Patent No. 6,551,838, “Microfabricated devices for the storage and selective exposure of chemicals and devices.” The patent covers a microchip device with reservoirs containing catalysts and reagents, and a sensor. The microchip can be used for environmental sensing.


Amersham Biosciences received US Patent No. 6,551,839, “Method of merging chemical reactants in capillary tubes.” The patent covers a system that contains capillary plumbing to enable fluid motion in a system of fibers that are controllable, allowing chemical reactions, and analysis at microliter volumes.


Cartesian Technologies of Irvine, Calif., received US Patent No. 6,551,557, “Tip design and random access array for microfluidic transfer.” The patent covers a ceramic tip for the transfer of samples from a source plate to a target, and a printhead for the transfer of microfluidic quantities for applications such as microarraying.


Roche Diagnostics received US Patent No. 6,552,199, “Fluorescence dyes and their use as fluorescence markers.” The patent covers new xanthene derivatives suitable for use as fluorescence dyes for application in DNA analytics.


Helix BioPharma of Aurora, Ontario, Canada, announced that it has received two European patents for its molecular sensing technology and its heterodimer protein technology, in addition to two US patents previously granted. The company is using the inventions in creating protein biochip arrays.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.