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Affymetrix, Incyte, The University of Kentucky Research Foundation, PE Corporation/Applera

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Affymetrix has received US Patent Number 6,420,169, “Apparatus for forming polynucleotides or polypeptides.” The patent covers a method for in situ synthesis of oligonucleodides, first by irradiating a predefined region of the substrate to deprotect the substrate. A nucleotide is then added to the substrate in the irradiated region, and is coupled to it. These steps are repeated in order to create an array of oligonucleotides.

 

Incyte has been awarded US Patent Number 6,420,114, “Microarray hybridization chamber.” The patent describes a chamber for mixing a film of fluid, and a method for mixing the fluid by creating a bubble and moving the bubble around in the fluid.

 

The University of Kentucky Research Foundation in Lexington, Ky., has received US Patent Number 6,420,105, “Method for analyzing molecular expression or function in an intact single cell.” The patent covers a technique in which the molecular contents of an intact cell can be detected. The method involves isolating the cell from its organ tissue by subjecting the tissue to a dissociation method, and collecting it with a device that can ensure it remains intact; withdrawing device, then isolating the molecules in the single cell.

 

PE Corporation, now Applera, has been awarded US Patent Number 6,416,990, “Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof.” The patent describes amino acid sequences of kinase peptides, and the peptide molecules, as well as the nucleic acid molecules that encode them. It also provides methods of identifying orthologous and paralogous molecules, as well as modulators of the peptides.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.