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Affymetrix, Cellomics


Affymetrix said this week that it will launch its new scanner, the GeneChip Scanner 3000, at the Lab Automation 2003 convention in Palm Springs, Calif., Feb. 2-4 (see page 1).

Pittsburg-based Cellomics rolled out three software modules for its ArrayScan High Content Screening Reader and the vHCS Discovery ToolBox this week. The Molecular Translocation module allows the study of multiple signal transduction pathways involving biomolecules such as transcription factors and kinases within a single experiment. Up to five individual translocation events can be measured in each cell and reporting features indicate population characteristics and correlations between multiple targets.The Micronucleus application is a multi-channel module that enables detection of genotoxicity by examining the frequency of micronucleus formation in mononucleate or binucleate cells. The Cell Cycle application is also a multi-channel software that is used to measure the cell-cycle phase of individual cells within a population by measuring DNA content and correlating this with the activity of multiple other cell cycle-associated proteins in each cell. Then, the application uses population analysis and classification to determine the distribution of phases for individual cells.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.