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Affymetrix, California Institute of Technology, UT-Battelle, Sigma Genosys, Commissariart A L Energie Atomique, Fuli Photo Film


Affymetrix of Santa Clara, Calif., has received US Patent No. 6,804,670, “System, method, and user interfaces for managing genomic data.” A data manager is described for providing a database for access by data mining tools and other data processing software applications. The data manager includes a results-for-publication identifier that identifies synthesized probe array results and spotted probe array results for publishing. This identification may be based, at least in part, on user selections. The data in the database is organized in accordance with an integrated database schema. The data manager may also include an experimental results registration processor that registers the synthesized probe array results and the spotted probe array results for publishing.

California Institute of Technology in Pasadena, Calif., has received US Patent No. 6,804,062, “Nonimaging concentrator lens arrays and microfabrication of the same.” This project encompassed design and fabrication of a single pixel for a solar concentrator photovoltaic monolithic microarray. Photovoltaic concentrators offer a competitive electricity cost. Such concentrating microarrays may enable photovoltaic cells with 40 percent to 50 percent efficiency using III-V compound heterostructures. The main components of the design include a thin-film solar cell, an array of soft polymer microlenses to optimally concentrate solar radiation, and a heat sink to manage the heat dissipated. Microlens arrays were fabricated in polydimethylsiloxane (PDMS) using soft lithography techniques and the optical properties (absorbance, lens magnification, aberrations, etc.) were characterized. The results indicate that such microarrays can be used for a monolithic concentrating photovoltaic array.

UT-Battelle of Oak Ridge, Tenn., has been granted US Patent No. 6,803,566, “Sampling probe for microarray readout using electrospray mass spectrometry.” The patent covers an automated electrospray based sampling system and method for analysis that obtains samples from surface array spots having analytes. The system includes at least one probe, which includes an inlet for flowing at least one eluting solvent to respective ones of a plurality of spots and an outlet for directing the analyte away from the spots. An automatic positioning system is provided for translating the probe relative to the spots to permit sampling of any spot. An electrospray ion source having an input connected via fluid to the probe receives the analyte and generates ions from the analyte. The ion source provides the generated ions to a structure for analysis to identify the analyte, preferably being a mass spectrometer.

Sigma Genosys of The Woodlands, Texas, has received US Patent No. 6,803,238, “Methods for multiplexed biochemical analysis.” The invention provides methods for detecting a labeled sample molecule bound to an immobilized probe by electrochemiluminescence. The method comprises a multiplexed molecular analysis system that includes a reaction chamber comprising a reaction substrate of biosites, with each biosite having a plurality of similar capture probes attached to the reaction substrate. The reaction substrate contains an embedded conductive material connected to an electrical source and provides a sample comprising a plurality of molecules labeled with a electrochemiluminescent label. Adding a solution comprising this sample to the reaction chamber and applying a voltage from the electrical source to the conductive material — after sufficient time has passed for a labeled molecule to bind to a capture probe — induces an electrochemical event within the electrochemiluminescent label that releases a detectable amount of electromagnetic energy.

Commissariart A L’Energie Atomique of Paris, France, has received US Patent No. 6,803,228, “Method for making a biochip and biochip.” The patent covers a method to produce a biochip and the biochip itself, which is composed particularly of biological probes grafted onto a conductive polymer. The method according to the invention comprises the following steps: a) structuring of a substrate so as to obtain on said substrate microtroughs comprising in their base a layer of a material capable of initiating and promoting the adhesion onto said layer of a film of a pyrrole and functionalised pyrrole copolymer by electropolymerisation; b) collective electropolymerisation, so as to form an electropolymerised film of a pyrrole and functionalised pyrrole copolymer on the base of said microtroughs; and c) direct or indirect fixation of functionalised oligonucleotides by microdeposition or a liquid jet printing technique.

Fuli Photo Film of Kanagawa-Ken, Japan, has been granted US Patent No. 6,801,644, “Method and apparatus for selectively displaying measurement result and corresponding images.” The patent covers an image display apparatus that provides a measurement result table including a plurality of lists, each of which is obtained from at least two corresponding measurement spots in at least two images.


The Scan

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Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.