Affymetrix of Santa Clara, Calif. has received US Patent No. 6,924,094, "Chip-based species identification and phenotypic characterization of microorganisms." The patent describes oligonucleotide-based arrays and methods for speciating and phenotyping organisms by using oligonucleotide sequences based on different genes. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database, according to the patent.
Affymetrix has also received US Patent No. 6,927,032, "Expression monitoring by hybridization to high density oligonucleotide arrays." This patent provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. One embodiment of the patented invention involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, and hybridizing the pool of nucleic acids to an array of oligonucleotide probes immobilized on a surface, and quantifying the hybridized nucleic acids in the array.The array should comprise more than 100 different oligonucleotides with a density greater than about 60 different oligonucleotides per 1 cm2.
Bio-Informatics Group of Raleigh, NC, has received US Patent No. 6,924,107, "Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip." The patented invention provides a 4D biochip containing a number of 3D biochips having a predetermined number of capillaries, where the capillaries each contain a biological factor, and methods for preparing and using the 4D biochip to provide assays of large quantities of samples and/or factors.