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Affymetrix, Agilent Technologies, Maven Technologies

Affymetrix has received US Patent No. 7,125,161, “Methods for mixing fluid in a rotating container.” The patent claims devices, systems, and methods for mixing biological fluids, where one device is adapted for holding at least one cartridge having a planar-faced chamber containing a biological fluid. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body so that the face of the chamber is generally perpendicular to the rotational axis, according to the patent’s abstract.

Affymetrix has also received US Patent No. 7,125,947, “Functionalized silicon compounds and methods for their synthesis and use.” The patent claims functionalized silicon compounds that include at least one activated silicon group and at least one derivatizable functional group. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces that may then be used in a wide range of different applications such as providing a functionalized surface on a substrate to which molecules may be attached. The method also enables the formation of high-density arrays of nucleic acids immobilized on a substrate, which may be used in conducting high-volume nucleic acid hybridization assays, the patent’s abstract states.

Agilent Technologies has received US Patent No. 7,125,523, “Holders for arrays.” The patent claims a holder for an array unit having a planar substrate and an array of chemical moieties on a surface of the substrate. The holder may include a body with a retaining mechanism that retains an array unit in a seated position, according to the patent’s abstract. The holder identifier may also include data on a characteristic of the holder or seated array or be linkable to a file containing such information. An apparatus, method, and computer program product that may be used with such a holder are also described.


Maven Technologies of Los Angeles has received US Patent No. 7,126,688, “Microarray scanning.” The patent claims methods and an apparatus for scanning a microarray to provide an image of the microarray. Data related to change in polarization state of a scanning light beam for individual points or lines or other portion of the microarray are collected and then processed to image the microarray at high resolution and speed.

The Scan

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.

Clinical Trial Participants, Investigators Point to Importance of Clinical Trial Results Reporting in Canadian Study

Public reporting on clinical trial results is crucial, according to interviews with clinical trial participants, investigators, and organizers from three provinces appearing in BMJ Open.

Old Order Amish Analysis Highlights Autozygosity, Potential Ties to Blood Measures

Researchers in BMC Genomics see larger and more frequent runs-of-homozygosity in Old Order Amish participants, though only regional autozygosity coincided with two blood-based measures.

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.